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Dajeong Kim
Seoul National University
NanotechnologyMaterials scienceDNARNACell biology
13Publications
4H-index
34Citations
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Publications 13
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#1Dajeong Kim (SNU: Seoul National University)H-Index: 4
#2Ji-Eun Kim (SNU: Seoul National University)H-Index: 29
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DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer-protein interaction, to expedite hemostasis over a large area. The DNA film decorated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic am...
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#1Dajeong Kim (SNU: Seoul National University)H-Index: 4
#2Hye-Jin Kim (SNU: Seoul National University)H-Index: 31
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The transdermal delivery of functional biomolecules has been widely achieved by microneedles in a non-invasive manner. However, establishing a simple and universal way to assure a stable loading of a large number of drugs is still imperative, particularly for the delivery of nucleic acid-based drugs. To address this issue, here, we present a universally applicable RNA membrane-coating system as a novel platform to manufacture purpose-oriented microneedles. Customization of RNA membrane-based mic...
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#1Hye-Jin Kim (SNU: Seoul National University)H-Index: 31
#2Dajeong Kim (SNU: Seoul National University)H-Index: 4
Last. Jong Bum Lee (SNU: Seoul National University)H-Index: 20
view all 6 authors...
Abstract Cells secrete extracellular vesicles (EVs) to external environments to achieve cellular homeostasis and cell-to-cell communication. Their therapeutic potential has been constantly spotlighted since they mirror both cytoplasmic and membranous components of parental cells. Meanwhile, growing evidence suggests that EV engineering could further promote EVs with a maximized capacity. In this review, a range of engineering techniques as well as upscaling approaches to exploit EVs and their mi...
2 CitationsSource
#1Daheui Choi (Yonsei University)H-Index: 10
#2Hye-Jin Kim (SNU: Seoul National University)H-Index: 31
Last. Jinkee Hong (Yonsei University)H-Index: 22
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: We report a novel approach for generating nanosized DNA hollow spheres (HSs) using enzymatically produced DNA microsponges in a self-templating manner. In previous studies, preparation of DNA nanostructures with specified functions required multiple complicated steps. In this study, however, a simple treatment with the nucleophilic agent 4-dimethylaminopyridine (DMAP) enabled a gradual disentanglement of DNA in microsponges by electrostatic interactions between DMAP and DNA, and the DNA underw...
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#1Heejung Jung (Konkuk University)H-Index: 3
#2Dajeong Kim (SNU: Seoul National University)H-Index: 4
Last. Hyejung Mok (Konkuk University)H-Index: 32
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Correction for ‘CpG incorporated DNA microparticles for elevated immune stimulation for antigen presenting cells’ by Heejung Jung et al., RSC Adv., 2018, 8, 6608–6615.
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#1Dajeong Kim (SNU: Seoul National University)H-Index: 4
#2Hyejin Kim (SNU: Seoul National University)H-Index: 1
Last. Jong Bum Lee (SNU: Seoul National University)H-Index: 20
view all 6 authors...
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#1Dajeong Kim (SNU: Seoul National University)H-Index: 4
#2Hyejin Kim (SNU: Seoul National University)H-Index: 1
Last. Jong-bum Lee (SNU: Seoul National University)
view all 6 authors...
: Self-assembled RNA particles have been exploited widely to maximize the therapeutic potential of RNA. However, the immune response via RNA particles is not fully understood. In addition, the investigation of the immunogenicity from RNA-based particles is required owing to inherent immunostimulatory effects of RNA for clinical translation. To examine the immune stimulating potency, rationally designed microsized RNA particles, called RNA microspheres (RMSs), are generated with single or double ...
4 CitationsSource
#1Hye-Jin Kim (SNU: Seoul National University)H-Index: 31
#2Dajeong Kim (SNU: Seoul National University)H-Index: 4
Last. Jong LeeH-Index: 1
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Thanks to a wide range of biological functions of RNA, and advancements in nanotechnology, RNA nanotechnology has developed in multiple ways for RNA-based therapeutics. In particular, among RNA engineering techniques, enzymatic self-assembly of RNA structures has gained great attention for its high packing density of RNA, with a low cost and one-pot synthetic process. However, manipulation of the overall size of particles, especially a reduction in size, has not been studied in depth. Here, we r...
2 CitationsSource
#1Heejung Jung (Konkuk University)H-Index: 3
#2Dajeong Kim (SNU: Seoul National University)H-Index: 4
Last. Hyejung Mok (Konkuk University)H-Index: 32
view all 6 authors...
As emerging evidence supports the immune stimulating capability of the CpG oligodeoxynucleotides (ODN), CpG-based adjuvants have been widely used. For efficient induction of immune responses, current issues affecting the use of nucleic acid-based adjuvants, e.g. stability in physiological conditions, delivery to immune cells, and successful release within the phagolysosome, should be addressed. Here, we present CpG-based DNA microparticles (DNA-MPs) fabricated by complementary rolling circle amp...
5 CitationsSource
#1Hye-Jin Kim (SNU: Seoul National University)H-Index: 31
#2Jaepil Jeong (SNU: Seoul National University)H-Index: 5
Last. Jong Bum Lee (SNU: Seoul National University)H-Index: 20
view all 6 authors...
As ribonucleic acid (RNA) nanotechnology has advanced, it has been applied widely in RNA-based therapeutics. Among the range of approaches, enzymatically synthesized RNA structures for inducing RNA interference in cancer cells have potential for silencing genes in a target-specific manner. On the other hand, the efficiency of gene silencing needs to be improved to utilize the RNA-based system for RNAi therapeutics. This paper introduces a new approach for efficient generation of siRNA from bubbl...
8 CitationsSource
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