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Friederike Schulze
University of Basel
Publications 4
Published on Feb 1, 2018in Cell Reports 7.82
Marianne Böni-Schnetzler21
Estimated H-index: 21
(University of Basel),
Stéphanie P. Häuselmann5
Estimated H-index: 5
(University of Basel)
+ 10 AuthorsPraxedis Martin10
Estimated H-index: 10
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
Published on Dec 1, 2017in Scientific Reports 4.01
Thierry M. Nordmann3
Estimated H-index: 3
(University of Basel),
Erez Dror7
Estimated H-index: 7
(University of Basel)
+ 5 AuthorsMarc Y. Donath57
Estimated H-index: 57
(University of Basel)
Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
Published on Mar 1, 2017in Nature Immunology 23.53
Erez Dror7
Estimated H-index: 7
Elise Dalmas7
Estimated H-index: 7
+ 17 AuthorsFriederike Schulze4
Estimated H-index: 4
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
Published on Mar 1, 2017in Cell Reports 7.82
Shuyang Traub5
Estimated H-index: 5
(University of Basel),
Daniel T. Meier2
Estimated H-index: 2
(University of Basel)
+ 11 AuthorsValmir Makshana1
Estimated H-index: 1
(University of Basel)
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...