Friederike Schulze
University of Basel
Publications 4
#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Thierry M. Nordmann (University of Basel)H-Index: 3
#2Erez Dror (University of Basel)H-Index: 7
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 8 authors...
Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
23 CitationsSource
#1Erez DrorH-Index: 7
#2Elise DalmasH-Index: 8
Last.Marc Y. DonathH-Index: 60
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The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
70 CitationsSource
#1Shuyang Traub (University of Basel)H-Index: 5
#2Daniel T. Meier (University of Basel)H-Index: 2
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 14 authors...
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...
28 CitationsSource