Hoay Yan Cheah
University of Malaya
ConjugateIn vivoSinglet oxygenPhthalocyaninePhotodynamic therapy
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Publications 4
#1Hoay Yan CheahH-Index: 3
#2Elena GallonH-Index: 5
Last. Lik Voon KiewH-Index: 11
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We previously developed a new zinc(II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity, and nonselectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near-infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environme...
2 CitationsSource
#1Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
#2Lik Voon Kiew (UM: University of Malaya)H-Index: 11
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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While nano-sized construct (NSC) use in medicine has grown significantly in recent years, reported unwanted side effects have raised safety concerns. However, the toxicity of NSCs to the cardiovascular system (CVS) and the relative merits of the associated evaluation methods have not been thoroughly studied. This review discusses the toxicological profiles of selected NSCs and provides an overview of the assessment methods, including in silico, in vitro, ex vivo and in vivo models and how they a...
4 CitationsSource
#1Lik Voon Kiew (UM: University of Malaya)H-Index: 11
#2Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 11 authors...
Abstract In photodynamic therapy (PDT), the low absorptivity of photosensitizers in an aqueous environment reduces singlet oxygen generation efficiency and thereby decreases photosensitizing efficacy in biological conditions. To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate ( 1-PG ) made from a new phthalocyanine ( Pc 1 ) monofunctionalized to allow adequate conjugation to PGA. The resulting 1-PG conjugate retained high absorptivity in the near-infrared (NI...
7 CitationsSource
#1Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
#2Olivera Šarenac (University of Belgrade)H-Index: 7
Last. Nina Japundžić-Žigon (University of Belgrade)H-Index: 8
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AbstractConjugation of Doxorubicin (DOX) to N-(2-Hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the i...
6 CitationsSource