Soo Han Bae
Yonsei University
Publications 36
#1Gahee Bahn (SKKU: Sungkyunkwan University)H-Index: 5
#2Jong-Sung Park (SKKU: Sungkyunkwan University)H-Index: 18
Last.Dong-Gyu Jo (SKKU: Sungkyunkwan University)H-Index: 37
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BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer’s disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA ( BACE1-AS ) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expression plays an important role in AD pathogenesis. We found that nuclear factor erythroid-derived 2-related factor 2 (NRF2/NFE2L2) represses the expression of BACE1 and BACE1-AS thr...
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Yu Seol Lee (Yonsei University)H-Index: 3
Last.Soo Han Bae (Yonsei University)H-Index: 17
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Abstract Nonalcoholic steatohepatitis (NASH) is a common liver disease associated with metabolic disorders, including obesity and type 2 diabetes (T2D). Despite its worldwide prevalence, there are no effective drugs for the treatment of NASH. The progression of NASH is mainly accelerated by reactive oxygen species (ROS)-induced lipotoxicity. The transcription factor known as nuclear factor erythroid 2-related factor 2 (Nrf2) is pivotal for the elimination of ROS. Accordingly, activators of Nrf2 ...
#1Jung Bok Lee (Yonsei University)H-Index: 19
#2Jeong Su Park (Yonsei University)H-Index: 7
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
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#1Da Hyun Lee (Yonsei University)H-Index: 6
#2Byung-Wan Lee (Yonsei University)H-Index: 29
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 11 authors...
1 CitationsSource
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Da Hyun Lee (Yonsei University)H-Index: 6
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 8 authors...
ABSTRACTSaturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is cruc...
#1Eugene B. ChangH-Index: 67
#2Dae Hee KimH-Index: 1
Last.Cheol-Young ParkH-Index: 34
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1 CitationsSource
#1Yu Seol Lee (Yonsei University)H-Index: 3
#2Jeong Su Park (Yonsei University)H-Index: 7
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 7 authors...
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder closely linked with type II diabetes (T2D). The progression of NAFLD is associated with the induction of lipogenesis through hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. An increase in lipogenesis induces endoplasmic reticulum (ER) stress and accelerates oxidative liver injury in the pathogenesis of NAFLD. Lobeglitazone, one of thiazolidinedione (TZDs), is used as an antidiabetic drug to lower ...
1 CitationsSource
#1Soo Hyun Kim (Yonsei University)H-Index: 16
#2Ghi Su Kim (SMC: Samsung Medical Center)H-Index: 28
Last.Myung-Shik Lee (Yonsei University)H-Index: 58
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ABSTRACTImpairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved agents for treating NASH, drugs that can enhance autophagy and modulate inflammasome pathways may be beneficial. Here, we investigated the novel mechanism of ezetimibe, a widely prescribed drug for hypercholesterolemia, as a therapeutic option for ameliorating NASH. Human liver samples with steatosis and NASH were anal...
20 CitationsSource
#1Seong-Yeon Bae (Ewha Womans University)H-Index: 3
#2Sanguine Byun (Incheon National University)H-Index: 1
Last.Kyunglim Lee (Ewha Womans University)H-Index: 16
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ABSTRACTTPT1/TCTP (tumor protein, translationally-controlled 1) is highly expressed in tumor cells, known to participate in various cellular activities including protein synthesis, growth and cell survival. In addition, TPT1 was identified as a direct target of the tumor suppressor TP53/p53 although little is known about the mechanism underlying the anti-survival function of TPT1. Here, we describe a role of TPT1 in the regulation of the MTORC1 pathway through modulating the molecular machinery ...
5 CitationsSource