M F Powers
University of Toledo Medical Center
6Publications
4H-index
149Citations
Publications 6
Newest
Published on Feb 6, 2004in Journal of Biological Chemistry 4.01
Andrew D. Beavis13
Estimated H-index: 13
(University of Toledo Medical Center),
M F Powers4
Estimated H-index: 4
(University of Toledo Medical Center)
Abstract The mitochondrial inner membrane anion channel (IMAC) carries a wide variety of anions and is postulated to be involved in mitochondrial volume homeostasis in conjunction with the K+/H+ antiporter, thus allowing the respiratory chain proton pumps to drive salt efflux. How it is regulated is uncertain; however, it is inhibited by matrix Mg2+ and matrix protons. Previously determined values for the IC50 suggested that the channel would be closed under physiological conditions. In a previo...
27 Citations Source Cite
Published on Apr 8, 1994in Journal of Biological Chemistry 4.01
M F Powers4
Estimated H-index: 4
,
L L Smith1
Estimated H-index: 1
,
Andrew D. Beavis13
Estimated H-index: 13
Abstract The mitochondrial inner membrane anion channel (IMAC) is a transport pathway which is believed to be involved in mitochondrial volume homeostasis. The protein, however, has not been identified. In this paper, we examine the relationship between IMAC and the adenine nucleotide translocator. Many inhibitors of the adenine nucleotide translocase are shown to block IMAC, including Cibacron blue 3GA, bromcresol green, alizarin red S, agaric acid, palmitoyl-CoA, and the fluorescein derivative...
13 Citations
Published on Sep 15, 1991in Journal of Biological Chemistry 4.01
M F Powers4
Estimated H-index: 4
,
Andrew D. Beavis13
Estimated H-index: 13
Abstract The inner membrane of liver and heart mitochondria possesses an anion uniport pathway, known as the inner membrane anion channel (IMAC). IMAC is inhibited by matrix Mg2+, matrix H+, N,N'-dicyclohexycarbodiimide, mercurials and amphiphilic amines such as propranolol. Most of these agents react with a number of different mitochondrial proteins and, therefore, more selective inhibitors have been sought. In this paper, we report the discovery of a new class of inhibitors, triorganotin compo...
63 Citations
Published on Oct 15, 1989in Journal of Biological Chemistry 4.01
Andrew D. Beavis13
Estimated H-index: 13
,
M F Powers4
Estimated H-index: 4
Abstract The inner membrane of mitochondria possesses a pH-regulated anion uniporter which is activated by depletion of matrix divalent cations with A23187 (Beavis, A. D., and Garlid, K. D. (1987) J. Biol. Chem. 262, 15085-15093). It is now shown that Cl- transport through this pathway is inhibited by Mg2+ and Ca2+. There appear to be two sites for inhibition by Mg2+. One has an IC50 = 38 microM at pH 7.4 and appears to be on the inside since it is only observed in the presence of A23187 (10 nmo...
37 Citations
1