Fuquan Zhang
Nanjing Medical University
Single-nucleotide polymorphismGenetic associationPopulationGeneticsSchizophrenia
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Publications 26
#1Phil H. LeeH-Index: 39
#2Verneri AnttilaH-Index: 31
Last. Jordan W. SmollerH-Index: 78
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Summary Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. ...
30 CitationsSource
#1Chenxing Liu (University of Melbourne)H-Index: 5
#2Tetsufumi Kanazawa (University of Melbourne)H-Index: 8
Last. Chad A. Bousman (University of Melbourne)H-Index: 22
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Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorp...
1 CitationsSource
#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Lin TianH-Index: 8
Last. Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
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Abstract The progress of schizophrenia at various stages is an intriguing question, which has been explored to some degree using single-modality brain imaging data, e.g. gray matter (GM) or functional connectivity (FC). However it remains unclear how those changes from different modalities are correlated with each other and if the sensitivity to duration of illness and disease stages across modalities is different. In this work, we jointly analyzed FC, GM volume and single nucleotide polymorphis...
#1Shuquan RaoH-Index: 2
#2Na LuoH-Index: 2
Last. Fuquan ZhangH-Index: 8
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1 CitationsSource
#1Qiang Wang (Sichuan University)H-Index: 27
#2Hei Man Wu (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 1
Last. Tao Li (Sichuan University)H-Index: 46
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Importance The underlying mechanism for individual differences in patient response to antipsychotic medication remains unknown. Objective To discover genes and gene sets harboring rare variants associated with short-term antipsychotic medication efficacy. Design, Setting, and Participants In this multicenter, open-label, randomized clinical trial conducted between July 6, 2010, and December 31, 2011, 3023 patients recruited in China of Chinese Han descent with schizophrenia with total Positive a...
2 CitationsSource
#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Jing SuiH-Index: 31
Last. Tianzi JiangH-Index: 67
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Abstract Background In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset. Methods Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-su...
3 CitationsSource
Jul 1, 2018 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Lin TianH-Index: 8
Last. Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
view all 9 authors...
Schizophrenia (SZ) is a highly heritable disease exhibiting substantial structural and functional brain impairments. The duration of illness and medication use may cause different presentations of impairments in patients. To understand the progressive variations of the disease, most recent studies have reported brain functional or structural abnormalities associated with illness duration, but a comprehensive study of pathology underlying brain structure, function and illness duration is still li...
1 CitationsSource
#1Hao Yu (PKU: Peking University)H-Index: 11
#2Hao Yan (PKU: Peking University)H-Index: 13
Last. Weihua Yue (PKU: Peking University)H-Index: 19
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Summary Background Antipsychotic drugs improve schizophrenia symptoms and reduce the frequency of relapse, but treatment response is highly variable. Little is known about the genetic factors associated with treatment response. We did a genome-wide association study of antipsychotic treatment response in patients with schizophrenia. Methods The discovery cohort comprised patients with schizophrenia from 32 psychiatric hospitals in China that are part of the Chinese Antipsychotics Pharmacogenomic...
18 CitationsSource
#1Sha Liu (Shanxi Medical University)H-Index: 5
#2Fuquan ZhangH-Index: 8
Last. Yong Xu (Shanxi Medical University)H-Index: 15
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There is an increasing interest in searching biomarkers for schizophrenia (SZ) diagnosis, which overcomes the drawbacks inherent with the subjective diagnostic methods. MicroRNA (miRNA) fingerprints have been explored for disease diagnosis. We performed a meta-analysis to examine miRNA diagnostic value for SZ and further validated the meta-analysis results. Using following terms: schizophrenia/SZ, microRNA/miRNA, diagnosis, sensitivity and specificity, we searched databases restricted to English...
9 CitationsSource