Julian I. Borissoff
Maastricht University
Neutrophil extracellular trapsImmunologyThrombinThrombusMedicine
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Publications 18
#1Jens Posma (UM: Maastricht University)H-Index: 2
#2Evrin Kilinç (UM: Maastricht University)
Last. Henri M. H. Spronk (UM: Maastricht University)H-Index: 39
view all 8 authors...
#1Alexander S. Savchenko (Harvard University)H-Index: 6
#2Kim Martinod (Harvard University)H-Index: 1
Last. Denisa D. Wagner (Harvard University)H-Index: 103
view all 10 authors...
Summary Background A growing health problem, venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), requires refined diagnostic and therapeutic approaches. Neutrophils contribute to thrombus initiation and development in experimental DVT. Recent animal studies recognized neutrophil extracellular traps (NETs) as an important scaffold supporting thrombus stability. However, the hypothesis that human venous thrombi involve NETs has not undergone rigorous tes...
91 CitationsSource
#1Alexander S. Savchenko (Boston Children's Hospital)H-Index: 6
#2Julian I. Borissoff (Boston Children's Hospital)H-Index: 11
Last. Denisa D. Wagner (Boston Children's Hospital)H-Index: 103
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Innate immune cells play a major role in the early response to myocardial ischemia/reperfusion (MI/R) injury. Recombinant human ADAMTS13 (rhADAMTS13), cleaving von Willebrand factor (VWF), reduces leukocyte recruitment in mice. Death of cardiomyocytes and the possible formation of neutrophil extracellular traps (NETs) may result in chromatin release that is prothrombotic and cytotoxic. We investigated the pathophysiological role of extracellular chromatin during MI/R to evaluate the therapeutic ...
98 CitationsSource
#1Henri M. H. Spronk (UM: Maastricht University)H-Index: 39
#2Julian I. Borissoff (Boston Children's Hospital)H-Index: 11
Last. Arina J. ten Cate-Hoek (UM: Maastricht University)H-Index: 64
view all 3 authors...
Thrombin is a pleiotropic enzyme that regulates hemostasis and nonhemostatic functions, including an array of actions within and on the vasculature. Physiologically, thrombin generation serves mainly to protect against thrombosis, but also to maintain vascular endothelial integrity. This protective effect is mediated in part through generation of anticoagulant enzymes, including activated protein C, formed on the action of thrombin on the endothelial receptor thrombomodulin. Partly, thrombin’s v...
13 CitationsSource
Objective—Aberrant neutrophil activation occurs during the advanced stages of atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil extracellular traps. This extracellular DNA exerts potent proinflammatory, prothrombotic, and cytotoxic properties. The goal of this study was to examine the relationships among extracellular DNA formation, coronary atherosclerosis, and the presence of a prothrombotic state. Approach and Results—In a prospective, observational, cross-...
153 CitationsSource
#1Julian I. Borissoff (UM: Maastricht University)H-Index: 11
#2Jeroen J. T. Otten (UM: Maastricht University)H-Index: 5
Last. Arina J. ten Cate-Hoek (UM: Maastricht University)H-Index: 64
view all 17 authors...
Background Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded contradictory findings on the role of hypercoagulability in atherogenesis. We therefore sought to address this matter by extensively investigating the in vivo significance of genetic alterations and pharmacologic inhibition of thrombin formation for t...
69 CitationsSource
#1Julian I. Borissoff (UM: Maastricht University)H-Index: 11
#2Ivo A. Joosen (UM: Maastricht University)H-Index: 11
Last. Leonard HofstraH-Index: 26
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Objectives This study sought to investigate the association between thrombin generation in plasma and the presence and severity of computed tomography angiographically defined coronary atherosclerosis in patients with suspected coronary artery disease (CAD). Background Besides its pivotal role in thrombus formation, experimental data indicate that thrombin can induce an array of pro-atherogenic and plaque-destabilizing effects. Although thrombin plays a role in the pathophysiology of atheroscler...
34 CitationsSource
#1Henri M. H. Spronk (UM: Maastricht University)H-Index: 39
#2Julian I. Borissoff (UM: Maastricht University)H-Index: 11
Last. Arina J. ten Cate-Hoek (UM: Maastricht University)H-Index: 64
view all 12 authors...
Abstract 103 Background: Besides its well-known role in initiation and propagation of thrombus formation, thrombin may have multiple pro-atherogenic actions. Hypothesis: Pharmacologic thrombin inhibition attenuates the onset and progression of atherosclerosis and favors plaque stability in hypercoagulable mice prone to aggressive atherosclerosis development. Methods and Results: Hypercoagulability in TM Pro/Pro :ApoE −/− mice resulted in severe atherosclerotic burden formation compared to ApoE −...
#1Peter AllanH-Index: 3
#2Sumitra MohanH-Index: 1
Last. Julian I. BorissoffH-Index: 11
view all 9 authors...
#1Joke Konings (UM: Maastricht University)H-Index: 7
#2José W. P. Govers-Riemslag (UM: Maastricht University)H-Index: 24
Last. Robert A. S. Ariëns (University of Leeds)H-Index: 41
view all 10 authors...
Recent data indicate an important contribution of coagulation factor (F)XII to in vivo thrombus formation. Because fibrin structure plays a key role in clot stability and thrombosis, we hypothesized that FXII(a) interacts with fibrin(ogen) and thereby regulates clot structure and function. In plasma and purified system, we observed a dose-dependent increase in fibrin fiber density and decrease in turbidity, reflecting a denser structure, and a nonlinear increase in clot stiffness with FXIIa. In ...
86 CitationsSource