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Agnes van Rossum
2Publications
2H-index
495Citations
Publications 2
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#2Agnes van RossumH-Index: 2
Last.Hein te RieleH-Index: 13
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The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression. We have generated an isogenic set of embryonic stem (ES) cell lines carrying single or compound loss-of-function mutations in the Rb gene family, including a cell line completely devoid of all three pocket proteins. None of the knockout combinations affected the growth characteristics of ES ce...
343 CitationsSource
#1Niels de Wind (American Association For Cancer Research)H-Index: 2
#2Marleen Dekker (American Association For Cancer Research)H-Index: 1
Last.Hein te RieleH-Index: 13
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Abstract Hemizygous germ-line defects in mismatch repair (MMR) genes underlie hereditary nonpolyposis colorectal cancer (HNPCC). Loss of the wild-type allele results in a mutator phenotype, accelerating tumorigenesis. Tumorigenesis specifically occurs in the gastrointestinal and genitourinary tracts; the cause of this tissue specificity is elusive. To understand the etiology and tissue distribution of tumors in HNPCC, we have developed mouse models carrying a deficiency in the MMR gene Msh2 . Mo...
152 Citations
1