Riccardo Nevola
Seconda Università degli Studi di Napoli
Publications 22
#1Luigi Elio AdinolfiH-Index: 34
#2Salvatore Petta (University of Palermo)H-Index: 41
Last.Antonio Craxì (University of Palermo)H-Index: 71
view all 21 authors...
Abstract Background and aims HCV is associated with an increased risk of cardiovascular events (CV). Whether HCV clearance by direct-acting antivirals (DAA) reduces incident CV disease is poorly understood. We investigate whether HCV eradication reduces CV events. Methods In a prospective multicentre study, 2204 HCV patients (F0–F2:29.5%, F3–F4: 70.5%) were enrolled. Males were 48%, median age was 68 (59–74) years and BMI 25.9 (23.1–28); 24.7% smoked, 18% had diabetes, 13.2% had cholesterol leve...
Abstract Metformin represents a striking example of a “historical nemesis” of a drug. About 40 years after its marketing in Europe, once demonstrated its efficacy and safety, metformin was registered also in the U.S. A few years later, it has become a mainstay in T2DM treatment, according to all international Scientific Societies guidelines. Today, despite the advent of new innovative drugs, metformin still persists as a first-choice drug in T2DM. This success is largely justified. In fact, over...
Background An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was the evaluation of early HCC occurrence rate and its risk factors in a HCV infected population, treated with direct-acting-antivirals.
Abstract Metformin, the first choice drug for type 2 diabetes treatment in all stages of therapy, and one of the most widely prescribed anti-hyperglycemic agent worldwide, represents a rare example of an old drug which continues to display new beneficial effects in various fields. However, lactic acidosis (LA) persists as a serious adverse effect. LA incidence is low and is not necessarily determined by the administration of metformin. Unfortunately, the concern for this complication has negativ...
1 CitationsSource
#1Luca RinaldiH-Index: 12
#2Maria Guarino (University of Naples Federico II)H-Index: 10
Last.Luigi Elio AdinolfiH-Index: 34
view all 16 authors...
Purpose The aim of this study was to evaluate the relationship between the liver stiffness measurement and the risk of developing hepatocellular carcinoma (HCC) in HCV cirrhotic patients undergoing new direct-acting antivirals.
Abstract Background and aims Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR–DKD in T2DM. Methods and results A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-se...
#1Teresa SalvatoreH-Index: 20
#2Riccardo NevolaH-Index: 6
Last.Ferdinando Carlo SassoH-Index: 25
view all 8 authors...
This review aimed to describe the potential mechanisms by which incretin hormones could mediate the relationship between glycemic index and cardiometabolic diseases. A body of evidence from many studies suggests that low glycemic index (GI) diets reduces the risk for type 2 diabetes and coronary heart disease. In fact, despite the extensive literature on this topic, the mechanisms underlying unfavorable effects of high GI foods on health remain not well defined. The postprandial and hormonal mil...
#1Rosa ZampinoH-Index: 23
#2Aldo MarroneH-Index: 18
Last.Luigi Elio AdinolfiH-Index: 34
view all 12 authors...
Purpose Endotoxin is a component of the outer membrane of gram-negative bacteria that live in the intestine. Endotoxinemia is reported in non-alcoholic fatty liver disease and in cirrhotic patients, causing various biological and clinical effects in the host. It is not known whether endotoxinemia occurs in chronic hepatitis C patients (CHC), therefore we evaluated the occurrence of endotoxinemia and its effect on inflammation, liver damage, insulin resistance (IR) and atherosclerosis.
3 CitationsSource
Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?
1 CitationsSource
#1Riccardo NevolaH-Index: 6
#2Luca RinaldiH-Index: 12
Last.Luigi Elio AdinolfiH-Index: 34
view all 5 authors...