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Henri-Alexandre Michaud
French Institute of Health and Medical Research
3Publications
1H-index
43Citations
Publications 3
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#1Yahya Ashraf (French Institute of Health and Medical Research)H-Index: 2
#2Hanane Mansouri (French Institute of Health and Medical Research)
Last.Emmanuelle Liaudet-Coopman (French Institute of Health and Medical Research)H-Index: 12
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Background Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an exciting treatment option for TNBC patients. The aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer (BC), is overproduced and hypersecreted by human BC cells. This study explores whether cath-D is a tumor cell-associated ext...
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#1Marion LapierreH-Index: 2
#2Cécile DejouH-Index: 4
Last.Nathalie Bonnefoy (French Institute of Health and Medical Research)H-Index: 10
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The CD39-CD73-adenosine pathway is an emerging regulator of the immune antitumor response. CD39 is expressed within tumors and the tumor microenvironment by several cell population including immune and cancer cells. In tumor tissues, the pathway leads to the accumulation of immunosuppressive adenosine together with decreased levels of immunoactivating peritumoral ATP. We reported previously that CD39 blockade increased T cell and NK cell-mediated cytotoxic activity in vitro and disclose, during ...
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#1Virginie Lafont (French Institute of Health and Medical Research)H-Index: 8
#2Françoise Sanchez (French Institute of Health and Medical Research)H-Index: 1
Last.Nathalie Bonnefoy (French Institute of Health and Medical Research)H-Index: 10
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The tumor immune microenvironment contributes to tumor initiation, progression and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of gamma and delta chains (gamma delta T cells) are of particular interest. gamma delta T cells can contribute to the immune response against many tumor types (lymphoma, myeloma, melanoma, breast, colon, lung, ovary and prostate cancer) directly through their...
43 CitationsSource
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