Match!
Yoonju Jung
Chung-Ang University
5Publications
3H-index
43Citations
Publications 5
Newest
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
AbstractAim: In this study, we report the anti-inflammatory activity of XAV939, a modulator of the Wnt/β-catenin pathway.Methods: WNT/β-catenin pathway and NF-κB signaling pathway were examined in LPS-stimulated human bronchial epithelial cells and effects of XAV939 on these pathways were analyzed. The effect of XAV939 was confirmed in human umbilical vein endothelial cells.Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-α, IL-1β, MCP-1, MMP-9, iNOS and COX-2 were sign...
2 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
Abstract Ethnopharmacological relevance Gangjihwan (DF) which is composed of Ephedra intermedia , Lithospermum erythrorhizon , and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. Aim of the study This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. Materials and methods The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol an...
3 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
11 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 6 authors...
Abstract In this study, TNF-α was found to activate the WNT/β-catenin pathway in BEAS-2B human bronchial epithelial cells. Levels of phospho-LRP6, Dvl-2, and phospho-GSK-3β were elevated, while that of Axin was reduced by TNF-α treatment. Nuclear translocation of β-catenin and the reporter activity of a β-catenin-responsive promoter were increased by TNF-α treatment. Under the same experimental conditions, TNF-α activated the NF-κB signaling, which includes the phosphorylation and degradation of...
7 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 5 authors...
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by Dickkopf-1 (DKK-1), a secreted Wnt antagonist, and LGK974, a small molecular inhibitor of the Wnt secretion. LPS-induced IκB degradation and NF-κB nuclear translocation as well as the expressions of pro-inflammatory genes including IL-6, IL-8, TNF- α, IL-1β, MCP-1, MMP-9, COX-2 and iNOS, were all suppressed by DKK-1 and LGK...
20 CitationsSource
1