Bryan D. Murray
Purdue University
VegetationEcologyPlant communityAgroforestryBiology
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Publications 14
#1John P. DeVincenzo (UT: University of Tennessee)H-Index: 37
#2Efi Gymnopoulou (Janssen Pharmaceutica)
Last. Jerald C. Sadoff (Janssen Pharmaceutica)H-Index: 60
view all 15 authors...
Background Despite the high disease burden of RSV in older adults and children, there is currently no approved vaccine. Ad26.RSV.preF, an experimental RSV vaccine, has demonstrated immunogenicity and tolerability in first-in-human clinical studies. The aim of this study was to assess the potential of the Ad26.RSV.preF vaccine to protect against RSV infection and disease in an established RSV human challenge model, used for the first time to evaluate a vaccine.
Background Respiratory syncytial virus (RSV) represents an important global health challenge with significant morbidity and mortality in infants, elderly, and immunocompromised adults. No effective therapy is currently available. EDP-938 demonstrates potent in vitro activity against RSV Subtypes A and B. We report data from EDP 938-101, a double-blind, placebo-controlled, Phase 2a study that evaluated EDP-938 in adult volunteers inoculated with RSV-A Memphis 37b.
#1Bryan D. Murray (Drake University)H-Index: 5
#2Jeffrey D. Holland (Purdue University)H-Index: 10
Last. Michael A. Jenkins (Purdue University)H-Index: 23
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Contemporary forest management offers a trade-off between the potential positive effects of habitat heterogeneity on biodiversity, and the potential harm to mature forest communities caused by habitat loss and perforation of the forest canopy. While the response of taxonomic diversity to forest management has received a great deal of scrutiny, the response of functional diversity is largely unexplored. However, functional diversity may represent a more direct link between biodiversity and ecosys...
6 CitationsSource
#1Daniel J. FullenH-Index: 2
#2Bryan D. MurrayH-Index: 5
Last. Rob Lambkin-WilliamsH-Index: 18
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Background Human Rhinovirus infection is an important precursor to asthma and chronic obstructive pulmonary disease exacerbations and the Human Viral Challenge model may provide a powerful tool in studying these and other chronic respiratory diseases. In this study we have reported the production and human characterisation of a new Wild-Type HRV-16 challenge virus produced specifically for this purpose. Methods and Stock Development A HRV-16 isolate from an 18 year old experimentally infected he...
5 CitationsSource
#1Bryan D. Murray (Purdue University)H-Index: 5
#2Christopher R. Webster (MTU: Michigan Technological University)H-Index: 26
Last. G. Scott Haulton (Indiana Department of Natural Resources)H-Index: 4
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Forest management and ungulate herbivory are extant drivers of herbaceous-layer community composition and diversity. We conducted a white-tailed deer (Odocoileus virginianus) exclosure experiment across a managed landscape to determine how deer impacts interact with the type of forest management system in influencing herb-layer (all vascular plants < 0.5 m tall) species richness and composition. Our study took place 3 yr after harvest in a deciduous forest landscape being managed through even-ag...
4 CitationsSource
#1Lindsay H. Jenkins (Purdue University)H-Index: 3
#2Bryan D. Murray (Purdue University)H-Index: 5
Last. Christopher R. WebsterH-Index: 26
view all 4 authors...
Abstract While hunting is employed as a means to control overabundant populations of white-tailed deer (Odocoileus virginianus) and reduce the negative effects of herbivory, few studies have examined whether recovery of forest regeneration occurs following a long-term controlled hunting program. In Indiana state parks, controlled hunts were implemented in the 1990s to reduce deer population abundance and allow vegetation communities to recover. In 1996 and 1997, long-term vegetation monitoring p...
10 CitationsSource
#1Betsy Tahtinen (MTU: Michigan Technological University)H-Index: 1
#2Bryan D. Murray (MTU: Michigan Technological University)H-Index: 5
Last. Andrew J. Burton (MTU: Michigan Technological University)H-Index: 36
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Concentrated foraging in forest canopy gaps by large ungulates may produce a pulsed spatial resource subsidy with cascading effects on the composition and developmental trajectory of gap vegetation. To test this hypothesis, we investigated the influence of white-tailed deer (Odocoileus virginianus) use of 12 artificial canopy gaps in a hemlock-northern hardwood forest. Ground-layer vegetation was monitored and available reactive nitrogen was assayed using resin beads deployed under the snowpack ...
8 CitationsSource
#1Bryan D. Murray (MTU: Michigan Technological University)H-Index: 5
#2Christopher R. Webster (MTU: Michigan Technological University)H-Index: 26
Last. Joseph K. Bump (MTU: Michigan Technological University)H-Index: 14
view all 3 authors...
Forest ungulates impact ecosystems in a number of ways. Most studies have focused on consumptive effects that may cascade to other components of the ecosystem, and tend to be motivated by harvest management or the mitigation of undesired effects on vegetation. In this study, we demonstrate that white-tailed deer (Odocoileus virginianus), a common forest ungulate in eastern North America, may directly increase availability and heterogeneity of nitrogen due to excretion of nitrogenous wastes. We c...
6 CitationsSource
#1Bryan D. Murray (MTU: Michigan Technological University)H-Index: 5
#2Christopher R. Webster (MTU: Michigan Technological University)H-Index: 26
Last. Joseph K. Bump (MTU: Michigan Technological University)H-Index: 14
view all 3 authors...
Spatial heterogeneity of soil resources, particularly nitrogen availability, affects herbaceous-layer cover and diversity in temperate forest ecosystems. Current hypotheses predict that ungulate herbivores influence nitrogen availability at the stand scale, but how ungulates affect nitrogen availability at finer spatial scales that are relevant to the herb layer is less understood. We tested the hypothesis that ungulate exclusion reduces the spatial complexity of nitrogen availability at neighbo...
33 CitationsSource
#1Bryan D. MurrayH-Index: 5