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Alexandra G. Lopez-Aguiar
Emory University
SurgeryPathologyNeuroendocrine tumorsGeneral surgeryMedicine
59Publications
5H-index
80Citations
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Publications 67
Newest
#1Jordan Baechle (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Paula Marincola Smith (VUMC: Vanderbilt University Medical Center)H-Index: 3
Last. Flavio G. Rocha (Virginia Mason Medical Center)H-Index: 10
view all 20 authors...
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are often indolent; however, identifying patients at risk for rapidly progressing variants is critical, particularly for those with small tumors who may be candidates for expectant management. Specific growth rate (SGR) has been predictive of survival in other malignancies but has not been examined in PNETs. METHODS: A retrospective cohort study of adult patients who underwent PNET resection from 2000 to 2016 was performed utilizing the multi-...
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#1Kota Sahara (The Ohio State University Wexner Medical Center)H-Index: 2
#2Diamantis I. Tsilimigras (The Ohio State University Wexner Medical Center)H-Index: 10
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 82
view all 22 authors...
Background The role of routine lymphadenectomy in the surgical treatment of pancreatic neuroendocrine tumors (pNET) remains poorly defined. The objective of the current study was to investigate trends in the number of lymph nodes (LN) evaluated for pNET treatment at a nationwide level.
2 CitationsSource
#1Paula Marincola Smith (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Jordan Baechle (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. Flavio G. Rocha (Virginia Mason Medical Center)H-Index: 10
view all 20 authors...
BACKGROUND: Insurance status predicts access to medical care in the USA. Previous studies have shown uninsured patients with some malignancies have worse outcomes than insured patients. The impact of insurance status on patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is unclear. PATIENTS AND METHODS: A retrospective cohort study of adult patients with resected GEP-NETs was performed using the US Neuroendocrine Tumor Study Group (USNETSG) database (2000-2016). Demographic an...
1 CitationsSource
#1James R. Barrett (UW: University of Wisconsin-Madison)H-Index: 1
#2Victoria R. Rendell (UW: University of Wisconsin-Madison)H-Index: 1
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 82
view all 19 authors...
BACKGROUND AND OBJECTIVES: Lack of high-level evidence supporting adjuvant therapy for patients with resected gastroenteropancreatic neuroendocrine tumors (GEP NETs) warrants an evaluation of its non-standard of care use. METHODS: Patients with primary GEP NETs who underwent curative-intent resection at eight institutions between 2000 and 2016 were identified; 91 patients received adjuvant therapy. Recurrence-free survival (RFS) and overall survival (OS) were compared between adjuvant cytotoxic ...
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#1Kota SaharaH-Index: 2
Last. Zaheer S. KanjiH-Index: 4
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BACKGROUND: The adoption of spleen-preserving distal pancreatectomy (SPDP) for malignant disease such as pancreatic neuroendocrine tumors (pNETs) has been controversial. The objective of the current study was to assess the impact of SPDP on outcomes of patients with pNETs. METHODS: Patients undergoing a distal pancreatectomy (DP) for pNET between 2002 and 2016 were identified in the U.S. Neuroendocrine Tumor Study Group database. Propensity score matching (PSM) was used to compare short- and lon...
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#1Alexandra G. Lopez-Aguiar (Emory University)H-Index: 5
#2Shishir K. Maithel (Emory University)H-Index: 38
Source
#1Dinghui Dong (Xi'an Jiaotong University)H-Index: 5
#2Xu-Feng Zhang (Xi'an Jiaotong University)H-Index: 6
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 82
view all 18 authors...
Abstract Background To define recurrence patterns and time course, as well as risk factors associated with recurrence following curative resection of pNETs. Method Patients who underwent curative-intent resection for pNET between 1997 and 2016 were identified from the US Neuroendocrine Tumor Study Group. Data on baseline and tumor-specific characteristics, overall survival (OS), timing and first-site of recurrence, predictors and recurrence management were analyzed. Results Among 1020 patients, ...
1 CitationsSource
#1Ding Hui Dong (Xi'an Jiaotong University)
#2Xu Feng Zhang (Xi'an Jiaotong University)H-Index: 7
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 82
view all 19 authors...
Abstract Background To investigate the feasibility of Tumor Burden Score (TBS) to predict tumor recurrence following curative-intent resection of non-functional pancreatic neuroendocrine tumors (NF-pNETs). Method The TBS cut-off values were determined by a statistical tool, X-tile. The influence of TBS on recurrence-free survival (RFS) was examined. Results Among 842 NF-pNETs patients, there was an incremental worsening of RFS as the TBS increased (5-year RFS, low, medium, and high TBS: 92.0%, 7...
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#1Paula Marincola Smith (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Jordan J. Baechle (Meharry Medical College)
Last. Kamran Idrees (VUMC: Vanderbilt University Medical Center)H-Index: 12
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Abstract Background Packed red blood cell (PRBC) transfusion has been associated with worse survival in multiple malignancies but its impact on pancreatic neuroendocrine tumors (PNETs) is unknown. The aim of this study was to determine the impact of PRBC transfusion on survival following PNET resection. Methods A retrospective cohort study of PNET patients was performed using the US Neuroendocrine Tumor Study Group database. Demographic and clinical factors were compared. Kaplan–Meier and log-ra...
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#1Emily A. Armstrong (The Ohio State University Wexner Medical Center)H-Index: 1
#1Emily A. Armstrong (OSU: Ohio State University)H-Index: 1
Last. Ryan C. Fields (WashU: Washington University in St. Louis)H-Index: 2
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The ACS established an online risk calculator to help surgeons make patient-specific estimates of postoperative morbidity and mortality. Our objective was to assess the accuracy of the ACS-NSQIP calculator for estimating risk after curative intent resection for primary GI neuroendocrine tumors (GI-NETs). Adult patients with GI-NET who underwent complete resection from 2000 to 2017 were identified using a multi-institutional database, including data from eight academic medical centers. The abilit...
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