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Dae Hyeok Yang
Catholic University of Korea
47Publications
12H-index
676Citations
Publications 48
Newest
#1Young-Bum Yoo (Konkuk University)H-Index: 5
#2Gayoung JoH-Index: 2
Last.Hoon HyunH-Index: 22
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#1Hyun Joo Kim (Catholic University of Korea)H-Index: 4
#2Su Jung You (Catholic University of Korea)H-Index: 1
Last.Moon Suk Kim (Ajou University)H-Index: 35
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Abstract The arginine-glycine-aspartic acid (RGD) motif plays a critical role in cell-extracellular matrix (ECM) interactions through focal adhesion, which may orchestrate various aspects of cellular behaviors for development and maintenance of tissues. Here, we prepared novel thermosensitive hydrogel systems comprising methoxy polyethylene glycol-b-polycaprolactone (MP) and RGD-conjugated MP (MP-RGD) with various RGD contents (MP/MP-RGD) based on our recently patented technology. The conjugatio...
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#1Hoon Hyun (Chonnam National University)H-Index: 6
#2Young-Bum Yoo (Konkuk University)H-Index: 5
Last.Dae Hyeok Yang (Catholic University of Korea)H-Index: 12
view all 6 authors...
Abstract Optimization of ligand density on polymeric nanoparticles (PNPs) is critical for targeting solid tumors. Here, we prepared fluorescent cyanine 5.5 dye and cyclo(arginine-glycine-aspartic acid-phenylalanine-lysine) ligand-modified polyethylene glycol-poly(lactic-co-glycolic acid) (Cy 5.5-cRGDfK-PEG-PLGA) NPs with different ligand concentrations and investigated their cancer-targeting abilities in vitro and in vivo. The PNPs self-assembled in an aqueous solution as round particles and sho...
1 CitationsSource
#1Sun-Jung YoonH-Index: 13
Last.Dae Hyeok YangH-Index: 12
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Osteosarcoma (OSA) is a difficult cancer to treat due to its tendency for relapse and metastasis; advanced methods are therefore required for OSA treatment. In this study, we prepared a local drug-delivery system for OSA treatment based on doxorubicin·hydrochloride (DOX·HCl)/cisplatin (CP)-loaded visible light-cured glycol chitosan (GC) hydrogel/(2-hydroxypropyl)-beta-cyclodextrin (GDHCP), and compared its therapeutic efficiency with that of DOX·HCl- and CP-loaded GC hydrogels (GD and GHCP). Bec...
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We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better an...
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#1Sungsu LeeH-Index: 2
#2Jin Seok JungH-Index: 3
Last.Hoon HyunH-Index: 22
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Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the h...
1 CitationsSource
#1Wonbong Lim (Chosun University)H-Index: 11
#2Bora Kim (Chosun University)H-Index: 2
Last.Hoon Hyun (Chonnam National University)H-Index: 6
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Bioluminescence imaging is being increasingly utilized in biological research. However, since the most commonly used firefly luciferase generates relatively weak bioluminescent signals, detection of low numbers of luciferase-expressing cells in vivo is challenging. The weak signal makes it difficult to detect cells located in deep tissues, which is problematic for preclinical research in tumor metastasis. In this study, three different types of fluorophores such as D-luciferin, AkaLumine-HCl, an...
2 CitationsSource
#1Yun Sung Lee (Catholic University of Korea)
#2Hyun Joo Kim (Catholic University of Korea)H-Index: 4
Last.Heung Jae Chun (Catholic University of Korea)H-Index: 10
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Abstract In this study, we prepared self-assembled micelles with methoxy poly(ethylene glycol)-b-poly(e-caprolactone) (MPEG-PCL) for paclitaxel (PTX) delivery. MPEG-PCL was synthesized by ring-opening polymerization in which the hydroxyl group was substituted for a carboxyl group by succinic anhydride. PTX was then coupled to carboxylated MPEG-PCL through esterification (MPEG-PCL-PTX). MPEG-PCL-PTX micelles were prepared by a solvent evaporation method. Conjugation of PTX to MPEG-PCL-PTX was con...
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#1Hoon Hyun (Chonnam National University)H-Index: 6
#2Sungsu Lee (Chonnam National University)H-Index: 1
Last.Heung Jae Chun (Catholic University of Korea)H-Index: 10
view all 11 authors...
Abstract In this study, we prepared a beta-cyclodextrin (β-CD)-based carrier consisting of β-CD, polyethylene glycol (PEG) and folic acid (FA) (CDPF) for improved doxorubicin (DOX) delivery to targeted breast cancer in vitro and in vivo. The morphology and size distribution were characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements, which revealed in particles ranging from 38 nm to 52 nm in size. DOX from CDPF was released in a sustained manner f...
1 CitationsSource
#1Deok-Won LeeH-Index: 13
#2Hoon HyunH-Index: 22
Last.Dae Hyeok YangH-Index: 12
view all 9 authors...
Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood ve...
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