Yitzhak Reizel
University of Pennsylvania
Cellular differentiationDNA demethylationDNA methylationDemethylationBiology
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Publications 4
#1Yitzhak Reizel (UPenn: University of Pennsylvania)H-Index: 3
#2Ashleigh R. Morgan (UPenn: University of Pennsylvania)H-Index: 1
Last. Klaus H. Kaestner (UPenn: University of Pennsylvania)H-Index: 95
view all 9 authors...
The FoxA transcription factors are critical for liver development through their pioneering activity, which initiates a highly complex regulatory network thought to become progressively resistant to the loss of any individual hepatic transcription factor via mutual redundancy. To investigate the dispensability of FoxA factors for maintaining this regulatory network, we ablated all FoxA genes in the adult mouse liver. Remarkably, loss of FoxA caused rapid hepatocyte dedifferentiation manifested by...
#1Yitzhak Reizel (UPenn: University of Pennsylvania)H-Index: 3
#2Ofra Sabag (HUJI: Hebrew University of Jerusalem)H-Index: 7
Last. Howard Cedar (HUJI: Hebrew University of Jerusalem)H-Index: 73
view all 15 authors...
Development in mammals is accompanied by specific de novo and demethylation events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a large percentage of the tissue-specific methylation pattern is generated postnatally. Demethylation in the liver is observed in thousands of enhancer-like sequences associated with genes that undergo activation during the first few weeks of life. Using. conditional gene ablation strategy we show that the removal of these methyl gro...
12 CitationsSource
#1Shari Orlanski (HUJI: Hebrew University of Jerusalem)H-Index: 6
#2Verena LabiH-Index: 22
Last. Yehudit Bergman (HUJI: Hebrew University of Jerusalem)H-Index: 37
view all 11 authors...
There is ample evidence that somatic cell differentiation during development is accompanied by extensive DNA demethylation of specific sites that vary between cell types. Although the mechanism of this process has not yet been elucidated, it is likely to involve the conversion of 5mC to 5hmC by Tet enzymes. We show that a Tet2/Tet3 conditional knockout at early stages of B-cell development largely prevents lineage-specific programmed demethylation events. This lack of demethylation affects the e...
36 CitationsSource
#1Yitzhak Reizel (HUJI: Hebrew University of Jerusalem)H-Index: 3
#2Adam Spiro (Weizmann Institute of Science)H-Index: 8
Last. Howard Cedar (HUJI: Hebrew University of Jerusalem)H-Index: 73
view all 8 authors...
DNA methylation patterns are set up in a relatively fixed programmed manner during normal embryonic development and are then stably maintained. Using genome-wide analysis, we discovered a postnatal pathway involving gender-specific demethylation that occurs exclusively in the male liver. This demodification is programmed to take place at tissue-specific enhancer sequences, and our data show that the methylation state at these loci is associated with and appears to play a role in the transcriptio...
28 CitationsSource