Hong Ma
Oregon National Primate Research Center
Publications 71
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Tomonari Hayama (Oregon National Primate Research Center)H-Index: 8
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 21 authors...
#1Eunju Kang (Oregon National Primate Research Center)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
2 CitationsSource
#1Hong MaH-Index: 27
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Yeonmi Lee (Oregon National Primate Research Center)H-Index: 6
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 15 authors...
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
1 CitationsSource
#1Ming-Tao Zhao (Stanford University)H-Index: 12
#2Haodong Chen (Stanford University)H-Index: 12
Last.Joseph C. Wu (Stanford University)H-Index: 91
view all 18 authors...
Abstract Patient-specific pluripotent stem cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pluripotent stem cells, iPSCs) or by somatic cell nuclear transfer (SCNT). However, abnormalities and preclinical application of differentiated cells generated by different reprogramming mechanisms have yet to be evaluated. Here we investigated the molecular and functional features, and drug response of cardiomyocytes (PSC-CMs) and endothelial cells (PSC-ECs)...
18 CitationsSource
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat MitalipovH-Index: 36
view all 31 authors...
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
328 CitationsSource
#1Hong Ma (OHSU: Oregon Health & Science University)H-Index: 27
#2Ryan C. O’Neil (UCSD: University of California, San Diego)H-Index: 5
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 26 authors...
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
25 CitationsSource
#1Don P. WolfH-Index: 42
#2Robert MoreyH-Index: 10
Last.Shoukhrat MitalipovH-Index: 36
view all 7 authors...
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
10 CitationsSource
#1Eunju Kang (UOU: University of Ulsan)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
89 CitationsSource
#1Ming-Tao Zhao (Cardiovascular Institute of the South)
#2Haodong Chen (Cardiovascular Institute of the South)H-Index: 12
Last.Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 13 authors...
Human pluripotent stem cells (PSCs) hold great promise for disease modeling, drug discovery, and regenerative medicine. Currently, patient-specific PSCs can be created via two approaches: somatic cell nuclear transfer (SCNT) by enucleated oocytes and iPSC reprogramming by ectopic expression of four transcription factors. Recent studies suggest that human SCNT-derived embryonic stem cells (nt-ESCs) are more similar to in vitro fertilized embryo derived ESCs (IVF-ESCs) than iPSCs at both transcrip...