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Hong Ma
Oregon National Primate Research Center
69Publications
27H-index
3,046Citations
Publications 69
Newest
Published on Mar 1, 2019in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
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Published on Sep 11, 2018
Hong Ma27
Estimated H-index: 27
,
Nuria Marti-Gutierrez1
Estimated H-index: 1
+ 27 AuthorsRiffat Ahmed10
Estimated H-index: 10
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Published on Jul 24, 2018in PLOS ONE 2.77
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
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Ming Tao Zhao2
Estimated H-index: 2
(Stanford University),
Haodong Chen11
Estimated H-index: 11
(Stanford University)
+ 15 AuthorsYoungkyun Kim9
Estimated H-index: 9
(Stanford University)
Abstract Patient-specific pluripotent stem cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pluripotent stem cells, iPSCs) or by somatic cell nuclear transfer (SCNT). However, abnormalities and preclinical application of differentiated cells generated by different reprogramming mechanisms have yet to be evaluated. Here we investigated the molecular and functional features, and drug response of cardiomyocytes (PSC-CMs) and endothelial cells (PSC-ECs)...
14 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Jan 1, 2017in Cell Stem Cell 23.29
Hong Ma27
Estimated H-index: 27
(Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
21 Citations Source Cite
Published on Jan 1, 2017in Stem Cells 5.59
Don P. Wolf42
Estimated H-index: 42
,
Robert Morey9
Estimated H-index: 9
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
9 Citations Source Cite
Published on Dec 1, 2016in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(University of Ulsan),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon Health & Science University)
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
70 Citations Source Cite
Published on Nov 11, 2016in Circulation 18.88
Mingtao Zhao (Cardiovascular Institute of the South), Haodong Chen11
Estimated H-index: 11
(Cardiovascular Institute of the South)
+ 10 AuthorsRebecca Tippner-Hedges9
Estimated H-index: 9
(Oregon Health & Science University)
Human pluripotent stem cells (PSCs) hold great promise for disease modeling, drug discovery, and regenerative medicine. Currently, patient-specific PSCs can be created via two approaches: somatic cell nuclear transfer (SCNT) by enucleated oocytes and iPSC reprogramming by ectopic expression of four transcription factors. Recent studies suggest that human SCNT-derived embryonic stem cells (nt-ESCs) are more similar to in vitro fertilized embryo derived ESCs (IVF-ESCs) than iPSCs at both transcrip...
Published on Sep 10, 2016in Stem Cells 5.59
Don P. Wolf42
Estimated H-index: 42
(Oregon Health & Science University),
Robert Morey9
Estimated H-index: 9
(University of California, San Diego)
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
2 Citations Source Cite
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