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K. Jelli
240Publications
59H-index
14.4kCitations
Publications 239
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Myoclonus is a hyperkinetic movement disorder defined as brief, shock-like jerks caused by muscular contractions or inhibitions. The neuroanatomical localization of myoclonus spans the CNS with origins in the cortex, brainstem, or spinal cord. Electrophysiologic studies (for example, EEG, multichannel surface EMG, long-latency EMG responses to nerve stimulation, EEG–EMG back-averaging, and somatosensory evoked potentials) can assist in determining its localization. These studies can also help in...
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Alzheimer’s disease (AD) and diabetes mellitus (DM) are the two most common and devastating health problems in the elderly. DM is a known risk factor for the development of cognitive dysfunction and dementia. Epidemiological and biological evidences support a link between type 2 DM (T2DM) and AD, but the precise mechanisms involved in the development of cognitive impairment in diabetics are not fully understood. Possible pathogenic pathways include genetic factors, ageing, ApoE status, hypo- and...
1 CitationsSource
M system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder of uncertain aetiology, presenting with autonomic failure variably combined with parkinsonism, cerebellar dysfunction, and pyramidal signs. The pathological process affects central autonomic, striatonigral and olivopontocerebellar systems showing varying degrees of degeneration that underlie the stratification of the heterogenous disorder into two major clinical variants correlating to the morphological phenotypes o...
2 CitationsSource
#1Hyeonjin Kim (SNU: Seoul National University)H-Index: 27
#2Beom S. Jeon (SNU: Seoul National University)H-Index: 32
Last.K. JelliH-Index: 59
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Because the progression of multiple system atrophy (MSA) is usually rapid and there still is no effective cause-related therapy, early and accurate diagnosis is important for the proper management of patients as well as the development of neuroprotective agents. However, despite the progression in the field of MSA research in the past few years, the diagnosis of MSA in clinical practice still relies largely on clinical features and there are limitations in terms of sensitivity and specificity, e...
15 CitationsSource
Multiple System Atrophy (MSA) is a rare adult-onset neurodegenerative disorder of uncertain etiology, clinically manifesting with parkinsonism, cerebellar impairment, autonomic dysfunction and pyramidal signs. The pathological process affects striatonigral, olivopontocerebellar, and autonomic nervous systems. The major clinical variants correlate to the morphologic phenotypes of striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C). Pathologically, MSA is characterized by G...
4 CitationsSource
2 CitationsSource
In their recent study on the evolution of mild parkinson signs (MPS) in aging, Mahoney et al. [4], in a cohort of 210 healthy older adults, none of them demented, MPS were observed in 45 %, 38 % of whom were transient (mean age 75.8 ± 7.37 years), while 61 % were persistent (mean age 79.8 ± 7.15 years). For the onset of MPS vascular mechanisms due to cardiovascular disease were suggested, and probably neurodegenerative mechanisms for the persistence of MPSs, while others suggested a multifactori...
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Alzheimer's Disease (AD) and Diabetes Mellitus (DM) are the two most common and devastating health problems in the elderly. They share a number of common features among which are important impact on quality of life and substantial health care costs. Epidemiological and biological evidence support a pathophysiological link between Type 2 Diabetes Mellitus (DMT2) and cognitive impairment (1-3). A causative association between DM and Alzheimer's disease has been suggested on the basis of clinical, ...
2 CitationsSource
SUMMARY Vascular cognitive impairment (VCI) defines a continuum of disorders ranging from mild cognitive impairment to full-blown dementia, attributable to cerebrovascular causes. Major morphological types – multi-infarct encephalopathy, strategic infarct type, subcortical arteriosclerotic leukoencephalopathy, multilacunar state, postischemic encephalopathy – result from systemic, cardiac and local large or small vessel disease. Cognitive decline is commonly caused by widespread small cerebrovas...
23 CitationsSource
#1K. JelliH-Index: 59
Parkinson’s disease (PD), one of the most frequent neurodegenerative disorders, is a progressive multiorgan proteinopathy caused by misfolded α-synuclein (α-syn) with variegated motor and nonmotor symptoms owing to a spreading process of synaptic and neuronal loss. Deposition of abnormal α-syn, the major protein marker of PD and other synucleinopathies, occurs first in presynaptic terminals and causes nerve cell loss and disturbance of neurotransmission via axonal degeneration. Morphological fea...
5 CitationsSource
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