Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
K. Jelli
236Publications
60H-index
14.6kCitations
Publications 236
Newest
Published on Dec 31, 2015in International journal of neurology
K. Jelli60
Estimated H-index: 60
(University of Vienna)
Alzheimer’s disease (AD) and diabetes mellitus (DM) are the two most common and devastating health problems in the elderly. DM is a known risk factor for the development of cognitive dysfunction and dementia. Epidemiological and biological evidences support a link between type 2 DM (T2DM) and AD, but the precise mechanisms involved in the development of cognitive impairment in diabetics are not fully understood. Possible pathogenic pathways include genetic factors, ageing, ApoE status, hypo- and...
K. Jelli60
Estimated H-index: 60
(University of Vienna)
M system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder of uncertain aetiology, presenting with autonomic failure variably combined with parkinsonism, cerebellar dysfunction, and pyramidal signs. The pathological process affects central autonomic, striatonigral and olivopontocerebellar systems showing varying degrees of degeneration that underlie the stratification of the heterogenous disorder into two major clinical variants correlating to the morphological phenotypes o...
Published on Aug 1, 2015in Journal of Neurology 4.20
Hyeonjin Kim25
Estimated H-index: 25
(SNU: Seoul National University),
Beom S. Jeon30
Estimated H-index: 30
(SNU: Seoul National University),
K. Jelli60
Estimated H-index: 60
Because the progression of multiple system atrophy (MSA) is usually rapid and there still is no effective cause-related therapy, early and accurate diagnosis is important for the proper management of patients as well as the development of neuroprotective agents. However, despite the progression in the field of MSA research in the past few years, the diagnosis of MSA in clinical practice still relies largely on clinical features and there are limitations in terms of sensitivity and specificity, e...
Published on Jun 30, 2015in International journal of neurology
K. Jelli60
Estimated H-index: 60
(University of Vienna)
Multiple System Atrophy (MSA) is a rare adult-onset neurodegenerative disorder of uncertain etiology, clinically manifesting with parkinsonism, cerebellar impairment, autonomic dysfunction and pyramidal signs. The pathological process affects striatonigral, olivopontocerebellar, and autonomic nervous systems. The major clinical variants correlate to the morphologic phenotypes of striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C). Pathologically, MSA is characterized by G...
Published on Jan 1, 2015in Journal of Neurology 4.20
K. Jelli60
Estimated H-index: 60
In their recent study on the evolution of mild parkinson signs (MPS) in aging, Mahoney et al. [4], in a cohort of 210 healthy older adults, none of them demented, MPS were observed in 45 %, 38 % of whom were transient (mean age 75.8 ± 7.37 years), while 61 % were persistent (mean age 79.8 ± 7.15 years). For the onset of MPS vascular mechanisms due to cardiovascular disease were suggested, and probably neurodegenerative mechanisms for the persistence of MPSs, while others suggested a multifactori...
K. Jelli60
Estimated H-index: 60
Alzheimer's Disease (AD) and Diabetes Mellitus (DM) are the two most common and devastating health problems in the elderly. They share a number of common features among which are important impact on quality of life and substantial health care costs. Epidemiological and biological evidence support a pathophysiological link between Type 2 Diabetes Mellitus (DMT2) and cognitive impairment (1-3). A causative association between DM and Alzheimer's disease has been suggested on the basis of clinical, ...
Published on Dec 1, 2014in Neurodegenerative disease management
K. Jelli60
Estimated H-index: 60
(University of Vienna)
SUMMARY Vascular cognitive impairment (VCI) defines a continuum of disorders ranging from mild cognitive impairment to full-blown dementia, attributable to cerebrovascular causes. Major morphological types – multi-infarct encephalopathy, strategic infarct type, subcortical arteriosclerotic leukoencephalopathy, multilacunar state, postischemic encephalopathy – result from systemic, cardiac and local large or small vessel disease. Cognitive decline is commonly caused by widespread small cerebrovas...
Published on Jan 1, 2014
K. Jelli60
Estimated H-index: 60
Parkinson’s disease (PD), one of the most frequent neurodegenerative disorders, is a progressive multiorgan proteinopathy caused by misfolded α-synuclein (α-syn) with variegated motor and nonmotor symptoms owing to a spreading process of synaptic and neuronal loss. Deposition of abnormal α-syn, the major protein marker of PD and other synucleinopathies, occurs first in presynaptic terminals and causes nerve cell loss and disturbance of neurotransmission via axonal degeneration. Morphological fea...
K. Jelli60
Estimated H-index: 60
Dementia, being not a specific disease but a syndrome characterized by deficits in several cognitive domains, is a major public health and socio-economic problem of our century. It is caused by dysfunction/loss of synapses and neurons inducing default neuronal networks. Despite updated concensus criteria for the clinical diagnosis of the major neurodegenerative disorders and new biomarkers, the diagnostic accuracy ranges from 65 to 96% (for Alzheimer’s disease /AD), with a sensitivity versus oth...
12345678910