Kyung Bok Lee
Konyang University
Molecular biologyChemistryDieckolBiochemistryBiology
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Publications 48
#1Young-Ju Lee (Konyang University)H-Index: 1
#2Jung-Hwan Park (Konyang University)H-Index: 3
Last. Sang-Muk Oh (Konyang University)H-Index: 7
view all 7 authors...
The phlorotannin compounds, dieckol and phlorofucofuroeckol (PFF), extracted from Ecklonia cava, have been suggested to exhibit anti-inflammatory, anti-adipogenic or anti-tumorigenic activity. However, role of dieckol or PFF in LPS/TLR-4 signaling that regulates cancer development still remains to be determined. Here we report that dieckol or PFF blocked lipopolysaccharide (LPS)-induced migration and invasion of human breast cancer MCF-7 or MDA-MB-231 cells by about 50% (p < 0.0001) or 60% (p = ...
#1Di Zhang (Jiangsu University)H-Index: 8
#2Chengtao Wang (BTBU: Beijing Technology and Business University)H-Index: 15
Last. Baoping Ji (CAU: China Agricultural University)H-Index: 28
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Numerous studies have been carried out on the redox activities of phenolic compounds from terrestrial plants, however, the redox pathway of phlorotannins, a type of marine algae-derived polyphenol, is far from clear. In the present study, the redox mechanisms of two phlorotannins, phloroglucinol (PL) and dieckol (DL), were comparatively scrutinized. Differential pulse voltammetry was conducted in the pH range 2.0–12.0 to determine the acid–base dissociation constant (pKa) and the number of elect...
2 CitationsSource
#1Guoyun Li (Ocean University of China)H-Index: 23
#2Lingyun Li (RPI: Rensselaer Polytechnic Institute)H-Index: 30
Last. Robert J. Linhardt (RPI: Rensselaer Polytechnic Institute)H-Index: 92
view all 9 authors...
In this report, we used liquid chromatography-mass spectrometry and Western blotting to analyze the content and structure of glycosaminoglycans, glycolipids and selected proteins to compare differences between patient-matched normal and cancerous lung tissues obtained from lung cancer patients. The cancer tissue samples contained over twice as much chondroitin sulfate (CS)/dermatan sulfate (DS) as did the normal tissue samples, while the amount of heparan sulfate (HS) and hyaluronan (HA) in norm...
6 CitationsSource
#1Jin-il KimH-Index: 5
#2Seong Gak JeonH-Index: 5
Last. Minho MoonH-Index: 23
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Platycodon grandiflorus (Jacq.) A.DC. (PG) has long been used as an ingredient of foods and is known to have beneficial effects on cognitive functions as well. The present study examined the effect of each PG extract (PGE) from root, aerial part, and seeds on cognitive functions in mice. Changes in spatial learning and memory using a Y-maze test, and markers of adult hippocampal neurogenesis and synaptogenesis were examined. Moreover, changes in neuritogenesis and activation of the ERK1/2 pathwa...
1 CitationsSource
#1Seok Joon KwonH-Index: 21
#2Dong Hee NaH-Index: 26
Last. Robert J. LinhardtH-Index: 92
view all 13 authors...
6’-Sialyllactose conjugated to polyamidoamine dendrimers at a well-defined valency and spacing can circumvent drug resistance and inhibit influenza A viruses.
23 CitationsSource
#1Jwa-Jin KimH-Index: 14
#2Yoon-Joong KangH-Index: 7
Last. Jae-Min Yuk (CNU: Chungnam National University)H-Index: 26
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Stroke is a complex neurodegenerative disorder with a clinically high prevalence and mortality. Despite many efforts to protect against ischemic stroke, its incidence and related permanent disabilities continue to increase. In this study, we found that pretreatment with phlorofucofuroeckol (PFF), isolated from brown algae species, significantly increased cell viability in glutamate-stimulated PC12 cells. Additionally, glutamate-stimulated cells showed irregular morphology, but PFF pretreatment r...
13 CitationsSource
#1Eun Ji Park (KNU: Kyungpook National University)H-Index: 12
#2Jae Eun Kim (Konyang University)H-Index: 2
Last. Dong Hee Na (KNU: Kyungpook National University)H-Index: 26
view all 6 authors...
3 CitationsSource
#1Jin‑A Choi (Konyang University)H-Index: 2
#2Yu Jin Jeong (Konyang University)H-Index: 4
Last. Jong-Hwan Park (Chonnam National University)H-Index: 11
view all 10 authors...
Although a Yersinia pseudotuberculosis (Yptb) lung infection model has been developed to study Y. pestis pathogenesis, it is still necessary to establish a new animal model to mimic the pathophysiological features induced by Y. pestis infection. Here, we provide a new lung infection model using the Yptb strain, IP2777, which displayed rapid spread of bacteria to the liver, spleen, and blood. In addition, we examined whether TLR4 is involved in Yptb-induced pathogenesis in the lung infection mode...
1 CitationsSource
#1Green Kim (Konyang University)H-Index: 1
#2Tae Hyoun Kim (SNU: Seoul National University)H-Index: 6
Last. Jong-Hwan Park (Korea Research Institute of Bioscience and Biotechnology)H-Index: 4
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Withaferin A (WA), a withanolide purified from Withania somnifera, has been known to exert anti-inflammatory effects. The present study sought to determine the effects of WA on Helicobacter (H.) pylori-mediated inflammation in the AGS gastric epithelial cell line. Cellular production of interleukin (IL)-8 and vascular endothelial growth factor (VEGF) was measured by ELISA. Western blot analysis was performed to determine the activation of nuclear factor (NF)-κB and mitogen-activated protein kina...
7 CitationsSource
#1Jun Young Lee (Chonnam National University)H-Index: 4
#2Eun Ha Hwang (Konyang University)H-Index: 1
Last. Jong-Hwan Park (Chonnam National University)H-Index: 11
view all 7 authors...
Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of bacterial peptidoglycan. Nod2 is critical for the initiation of the host immune response against M. tuberculosis infection, however the role of Nod1 remains largely unknown. We inve...
5 CitationsSource