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Viktoria C. Ruf
Ludwig Maximilian University of Munich
RadiologyPathologyChemistryGliomaMedicine
24Publications
5H-index
123Citations
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Publications 25
Newest
#1Viktoria C. Ruf (LMU: Ludwig Maximilian University of Munich)H-Index: 5
#2Song Shi (LMU: Ludwig Maximilian University of Munich)H-Index: 6
Last. Armin Giese (LMU: Ludwig Maximilian University of Munich)H-Index: 48
view all 8 authors...
Parkinson's Disease (PD) is a progressive neurodegenerative disease which is histologically characterized by loss of dopaminergic neurons in the substantia nigra and deposition of aggregated alpha-Synuclein (aSyn) in the brain. The detection of aSyn in well accessible fluids has been one of the central approaches in the development of biomarkers for PD. Recently, RT-QuIC (real-time quaking induced conversion) has been successfully adapted for use with aSyn seeds. Here, we systematically analysed...
Source
#1Viktoria C. Ruf (LMU: Ludwig Maximilian University of Munich)H-Index: 5
#2Anne Schöler (DKFZ: German Cancer Research Center)H-Index: 2
Last. Ulrich Schüller (UHH: University of Hamburg)H-Index: 9
view all 6 authors...
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#1Hans Helmut Niller (University of Regensburg)H-Index: 20
#2Klemens Angstwurm (University of Regensburg)H-Index: 9
Last. Barbara Schmidt (University of Regensburg)H-Index: 13
view all 43 authors...
Summary Background In 2018–19, Borna disease virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported in five human patients with severe to fatal encephalitis in Germany. However, information on case frequencies, clinical courses, and detailed epidemiological analyses are still lacking. We report the occurrence of BoDV-1-associated encephalitis in cases submitted to the Institute of Clinical Microbiology and Hygiene, Regensburg University ...
6 CitationsSource
#1M Kirchner (LMU: Ludwig Maximilian University of Munich)
#2Adrien Holzgreve (LMU: Ludwig Maximilian University of Munich)H-Index: 3
Last. Peter Bartenstein (LMU: Ludwig Maximilian University of Munich)H-Index: 58
view all 12 authors...
Source
#1Andreas Osterman (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Viktoria C. Ruf (LMU: Ludwig Maximilian University of Munich)H-Index: 5
Last. Hans-Walter Pfister (LMU: Ludwig Maximilian University of Munich)H-Index: 56
view all 14 authors...
BACKGROUND: Human encephalitis can originate from a variety of different aetiologies, of which infection is the most common one. The diagnostic work-up is specifically challenging in patients with travel history since a broader spectrum of unfamiliar additional infectious agents, e. g. tropical disease pathogens, needs to be considered. Here we present a case of encephalitis of unclear aetiology in a female traveller returning from Africa, who in addition developed an atypical herpes simplex vir...
1 CitationsSource
#1Georg Nuebling (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Eva Plesch (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Johannes Levin (LMU: Ludwig Maximilian University of Munich)H-Index: 30
view all 8 authors...
Background: While fibrillar deposits of hyperphosphorylated protein tau are a key hallmark of several neurodegenerative diseases such as Alzheimer’s disease, small oligomers have been speculated to be the key toxic aggregate species. Trivalent metal ions were shown to promote tau oligomer formation in vitro. However, little is known about potential intercellular spreading mechanisms or toxic modes of action of such oligomers. Methods: We investigated interactions of tau monomers and Fe3+/Al3+-in...
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#1Tasnim Chakroun (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Valentin Evsyukov (TUM: Technische Universität München)
Last. Günter U. HöglingerH-Index: 45
view all 10 authors...
Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate therapeutic target. Hence, to develop efficient disease-modifying strategies, it is fundamental to achieve a deeper understanding of the relevant spreading and toxic αSyn species. Here, we describe comparative and proof-of-principle approaches to determi...
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#1Marcus Unterrainer (LMU: Ludwig Maximilian University of Munich)H-Index: 12
#2Viktoria C. RufH-Index: 5
Last. Nathalie L. Albert (LMU: Ludwig Maximilian University of Munich)H-Index: 17
view all 10 authors...
AbstractA 51-year-old man presented with recurrent gliosarcoma and increasing cough over the last months. On 18F-FDG PET/CT, solid lung masses with high 18F-FDG uptake were present. A biopsy taken from a lung lesion indicated distant metastases from gliosarcoma. Gliosarcoma, a rare malignant central
1 CitationsSource
#1Marcus Unterrainer (LMU: Ludwig Maximilian University of Munich)H-Index: 12
#2D.F. Fleischmann (LMU: Ludwig Maximilian University of Munich)H-Index: 7
Last. Nathalie L. Albert (LMU: Ludwig Maximilian University of Munich)H-Index: 17
view all 18 authors...
Background The 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and represents an interesting target for glioma imaging. 18F-GE-180, a novel TSPO ligand, has shown improved binding affinity and a high target-to-background contrast in patients with glioblastoma. However, the association of uptake characteristics on TSPO PET using 18F-GE-180 with the histological WHO grade and molecular genetic features so far remains unknown and was evaluated in the current study.
1 CitationsSource
#1Philipp Sievers (DKFZ: German Cancer Research Center)H-Index: 7
#2Romain Appay (AMU: Aix-Marseille University)H-Index: 5
Last. David T. W. Jones (DKFZ: German Cancer Research Center)H-Index: 76
view all 35 authors...
Rosette-forming glioneuronal tumor (RGNT) is a rare brain neoplasm that primarily affects young adults. Although alterations affecting the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathway have been associated with this low-grade entity, comprehensive molecular investigations of RGNT in larger series have not been performed to date, and an integrated view of their genetic and epigenetic profiles is still lacking. Here we describe a genome-wide DNA met...
3 CitationsSource
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