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Tianyi Li
Center for Drug Evaluation and Research
EngineeringPrincipal component analysisPharmaceutical manufacturingMaterial propertiesChromatography
5Publications
3H-index
26Citations
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Publications 5
Newest
#1Yifan Wang (CDER: Center for Drug Evaluation and Research)H-Index: 9
#2Thomas O'Connor (CDER: Center for Drug Evaluation and Research)H-Index: 4
Last. Celia N. Cruz (CDER: Center for Drug Evaluation and Research)H-Index: 4
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Abstract The purpose of this study is to establish a material library and discuss its potential application to the development and lifecycle management of a continuous manufacturing process for solid dosage forms. Particularly, this study addresses the importance of selecting process-relevant testing conditions for material characterization, proposes a methodology to capture relevant information with a reduced set of measurements, and correlates material properties with process performance. This...
Source
#1Tianyi Li (RU: Rutgers University)H-Index: 3
#2James Scicolone (RU: Rutgers University)H-Index: 3
Last. Fernando J. Muzzio (RU: Rutgers University)H-Index: 52
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Purpose Powder properties, such as density and adhesion, can cause large variability in the flow rate of ingredients fed from feeders, which can propagate through the system. Knowing an ideal range of operation and correlating powder properties to process performance can result in faster optimization of performance, which saves time and money.
1 CitationsSource
#1Sara Moghtadernejad (RU: Rutgers University)H-Index: 8
#2M. Sebastian Escotet-Espinoza (RU: Rutgers University)H-Index: 5
Last. Fernando J. Muzzio (RU: Rutgers University)H-Index: 52
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As the pharmaceutical industry increasingly adopts continuous manufacturing technology, significant attention must be paid to process analytical technology (PAT), process integration, and process control. Published information is no substitute for hands-on comprehensive training, which is critical to implementing and operating continuous pharmaceutical manufacturing systems effectively and efficiently. In this article, an intensive hands-on training course has been developed and implemented at t...
3 CitationsSource
#1Yifan Wang (RU: Rutgers University)H-Index: 9
#2Juan G. Osorio (MIT: Massachusetts Institute of Technology)H-Index: 8
Last. Fernando J. Muzzio (RU: Rutgers University)H-Index: 52
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Abstract Purpose Lubrication is critical in pharmaceutical manufacturing of solid dosage forms. The purpose of this paper is to systematically compare and correlate the lubrication effect of two devices, a controlled shear system and a Resonant Acoustic Mixer, on the flow properties of pharmaceutical blends. Method A model formulation was selected. Full factorial designs were conducted to examine the effect of the total strain (or total energy) and the shear rate (or power) on the powder blend f...
3 CitationsSource
#1Yifan Wang (RU: Rutgers University)H-Index: 9
#2Tianyi Li (RU: Rutgers University)H-Index: 3
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract Purpose Accurate and consistent delivery of materials by well-designed feeders ensures overall process stability. Importantly, feeding performance is strongly dependent on material flow properties. The purpose of this study is to develop a methodology that identifies predictive correlation between material flow properties and feeder performance. Method The proposed methodology includes techniques to characterize material flow properties, methods to quantify feeding performance of a loss...
19 CitationsSource
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