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Sander Kersten
Wageningen University and Research Centre
EndocrinologyAdipose tissuePeroxisome proliferator-activated receptorBiochemistryBiology
240Publications
67H-index
16.4kCitations
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Publications 247
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#1Montserrat A. de la Rosa Rodriguez (WUR: Wageningen University and Research Centre)H-Index: 3
#2Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
Abstract Nearly all cell types have the ability to store excess energy as triglycerides in specialized organelles called lipid droplets. The formation and degradation of lipid droplets is governed by a diverse set of enzymes and lipid droplet-associated proteins. One of the lipid droplet-associated proteins is Hypoxia Inducible Lipid Droplet Associated (HILPDA). HILPDA was originally discovered in a screen to identify novel hypoxia-inducible proteins. Apart from hypoxia, levels of HILPDA are ind...
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#1Philip M. M. Ruppert (WUR: Wageningen University and Research Centre)H-Index: 3
#2Charlotte C. J. R. Michielsen (WUR: Wageningen University and Research Centre)H-Index: 1
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 7 authors...
Abstract Objective Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we aimed to validate this concept in humans by determining the effect of a prolonged fast on ANGPTL4 and LPL gene and protein expression in human subcutaneous adipose tissue. Methods To that end, twenty-three volunteers ate a standardized meal at 18.00h and fasted until 20.00h the next day. Blood was drawn and...
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#1Neha Shrestha (UM: University of Michigan)H-Index: 1
#2Tongyu Liu (UM: University of Michigan)H-Index: 4
Last. Chengyang Liu (UPenn: University of Pennsylvania)H-Index: 19
view all 16 authors...
beta-cell apoptosis and dedifferentiation are two hotly-debated mechanisms underlying beta-cell loss in type 2 diabetes; however, the molecular drivers underlying such events remain largely unclear. Here, we performed a side-by-side comparison of mice carrying beta-cell-specific deletion of endoplasmic reticulum (ER)-associated degradation (ERAD) and autophagy. We reported that while autophagy was necessary for beta-cell survival, the highly conserved Sel1L-Hrd1 ERAD protein complex was required...
1 CitationsSource
#1Alexandre Houzelle (UM: Maastricht University)H-Index: 3
#2Dennis Dahlmans (UM: Maastricht University)H-Index: 4
Last. Joris Hoeks (UM: Maastricht University)H-Index: 28
view all 9 authors...
Using an unbiased high-throughput microRNA (miRNA)-silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes, we previously identified 19 miRNAs as putative regulators of skeletal muscle mitochondrial metabolism. In the current study, we highlight miRNA-204-5p, identified from this screen, and further studied its role in the regulation of skeletal muscle mitochondrial function. Following silencing of miRNA-204-5p in C2C12 myotubes, gene and protein...
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#1Antwi-Boasiako Oteng (WUR: Wageningen University and Research Centre)H-Index: 2
#2Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
Human studies have established a positive association between the intake of industrial trans fatty acids and the development of cardiovascular diseases, leading several countries to enact laws that restrict the presence of industrial trans fatty acids in food products. However, trans fatty acids cannot be completely eliminated from the human diet since they are also naturally present in meat and dairy products of ruminant animals. Moreover, bans on industrial trans fatty acids have not yet been ...
2 CitationsSource
#1Zhangsen Zhou (UM: University of Michigan)
#2Mauricio Torres (UM: University of Michigan)H-Index: 1
Last. Allen H. Hunter (UM: University of Michigan)H-Index: 5
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The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affecte...
5 CitationsSource
#1Philip M. M. Ruppert (WUR: Wageningen University and Research Centre)H-Index: 3
#2Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
The enzyme lipoprotein lipase (LPL) is responsible for breaking down triglycerides in the blood. Mutations in LPL cause a rare but debilitating disorder characterized by excessive plasma triglyceride levels for which treatment options are limited. Nimonkar et al. now present a fusion protein between LPL and its physiological transporter GBIHBP1 that is highly active and largely resistant to physiological inhibitors of LPL. Injecting this fusion protein effectively lowers plasma triglycerides in ...
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#1Xanthe A. M. H. van Dierendonck (Radboud University Nijmegen)H-Index: 2
#2Montserrat A. de la Rosa Rodriguez (WUR: Wageningen University and Research Centre)H-Index: 3
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 10 authors...
Summary Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced adipose-tissue inflammation, using mice with myeloid-specific deficiency of the lipid-inducible HILPDA protein. HILPDA deficiency markedly reduced intracellular lipid levels and accumulation of fluorescently labeled fatty acids. Decreased lipid st...
2 CitationsSource
#2Mauricio TorresH-Index: 1
Last. Allen H. HunterH-Index: 5
view all 20 authors...
Organelles such as endoplasmic reticulum (ER) and mitochondria interact with each other at specialized domains on the ER known as mitochondria-associated membranes (MAMs). Here, using three-dimensional high-resolution imaging techniques, we show that the Sel1LHrd1 protein complex, the most conserved branch of ER-associated protein degradation (ERAD), exerts a profound impact on ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover and hence the abundan...
#1Eline N. Kuipers (LUMC: Leiden University Medical Center)H-Index: 4
#2Ntsiki M. Held (UvA: University of Amsterdam)H-Index: 5
Last. Mariëtte R. Boon (LUMC: Leiden University Medical Center)H-Index: 20
view all 11 authors...
Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high fat diet (HFD) feeding results in so-called 'whitening' ...
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