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Duanzhuo Li
Huazhong University of Science and Technology
5Publications
4H-index
91Citations
Publications 5
Newest
#1Shengjie LiaoH-Index: 5
#2Zhen Qu (HUST: Huazhong University of Science and Technology)H-Index: 3
Last.Duanzhuo LiH-Index: 4
view all 7 authors...
Abstract The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE eleme...
3 CitationsSource
#1Mi Huang (HUST: Huazhong University of Science and Technology)H-Index: 5
#2Duanzhuo LiH-Index: 4
Last.Mugen Liu (HUST: Huazhong University of Science and Technology)H-Index: 22
view all 13 authors...
Abstract The differentiation from constantly dividing epithelial cells into secondary fiber cells is a key step during lens development. Failure in this process, which requires cell proliferation inhibition and cell cycle exit, causes cataract formation. HSF4 (Heat Shock Transcription Factor 4) gene mutations may lead to both congenital and senile cataract. However, how HSF4 mutations induce cataract formation remains obscure. In this study, we demonstrate that HSF4 can suppress the proliferatio...
6 CitationsSource
#1Caie Zhang (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Duanzhuo Li (HUST: Huazhong University of Science and Technology)H-Index: 4
Last.Yunhua Deng (HUST: Huazhong University of Science and Technology)H-Index: 3
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Dyschromatosis universalis hereditaria (DUH) is a pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed randomly over the body. No causative genes have been reported to date. In this study, we investigated a large five-generation Chinese family with DUH. After excluding the two known DUH loci, we performed genome-wide linkage analysis and identified a DUH locus on chromosome 2q33.3-q36.1 with a maximum LOD score of 3.49 with marker D2S2382. ...
40 CitationsSource
#1Xiukun Cui (HUST: Huazhong University of Science and Technology)H-Index: 7
#2Lei Wang (HUST: Huazhong University of Science and Technology)H-Index: 5
Last.Mugen Liu (HUST: Huazhong University of Science and Technology)H-Index: 22
view all 13 authors...
HSF4 mutations lead to both congenital and age-related cataract. The purpose of this study was to explore the mechanism of cataract formation caused by HSF4 mutations. The degradation of nuclear DNA is essential for the lens fiber differentiation. DNase 2 beta (DLAD) is highly expressed in lens cells, and mice with deficiencies in the DLAD gene develop nuclear cataracts. In this study, we found that HSF4 promoted the expression and DNase activity of DIAD by directly binding to the DIAD promoter....
24 CitationsSource
#1Xiukun Cui (HUST: Huazhong University of Science and Technology)H-Index: 7
#2Jing Zhang (CAS: Chinese Academy of Sciences)H-Index: 7
Last.Mugen Liu (HUST: Huazhong University of Science and Technology)H-Index: 22
view all 15 authors...
Heat shock factor protein 4 (HSF4) is expressed exclusively in the ocular lens and plays a critical role in the lens formation and differentiation. Mutations in the HSF4 gene lead to congenital and senile cataract. However, the molecular mechanisms causing this disease have not been well characterized. DNA damage in lens is a crucial risk factor in senile cataract formation, and its timely repair is essential for maintaining the lens' transparency. Our study firstly found evidence that HSF4 cont...
18 CitationsSource
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