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J. Laschet
French Institute of Health and Medical Research
10Publications
1H-index
6Citations
Publications 10
Newest
#1Dimitri ArangalageH-Index: 5
#2T S Simon (French Institute of Health and Medical Research)
Last.J. Laschet (French Institute of Health and Medical Research)H-Index: 1
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#1Dimitri Arangalage (French Institute of Health and Medical Research)H-Index: 5
#2Marion Morvan (French Institute of Health and Medical Research)H-Index: 8
Last.J. Laschet (French Institute of Health and Medical Research)H-Index: 1
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Background Intraleaflet hematoma has been associated with advanced stages of aortic valve stenosis. Its presence is suspected to be involved in faster disease progression. However, the mechanism whereby the entry and the presence of blood elements into the valves would have an impact on the biology of aortic valvular interstitial cells (VICs) remains to be deciphered. Purpose To evaluate the presence of intraleaflet hematoma, in respect to calcium deposition, at all stages of aortic valve calcif...
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#1Guillaume EvenH-Index: 3
#2M. KissH-Index: 1
Last.Giuseppina CaligiuriH-Index: 42
view all 14 authors...
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#1Dimitri ArangalageH-Index: 5
#2Marion MorvanH-Index: 8
Last.J. LaschetH-Index: 1
view all 14 authors...
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#1V Syvannarath (French Institute of Health and Medical Research)
#2Sandrine Delbosc (French Institute of Health and Medical Research)H-Index: 14
Last.Giuseppina Caligiuri (French Institute of Health and Medical Research)H-Index: 42
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Introduction CD31 is a mechanosensory receptor and recent studies in CD31 knockout mice have suggested a protective role for CD31 in condition of altered mechanic stress such as in heart failure. Objective To directly assess the impact of CD31 signaling on the outcome of heart failure (HF) with both reduced and preserved ejection fraction (HFrEF and HFpEF, respectively). Method Permanent ligature of the proximal left coronary in C57Bl6 mice was used for modeling experimental HFrEF. Five days aft...
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#1Sandrine Delbosc (French Institute of Health and Medical Research)H-Index: 14
#2Richard Bayles (French Institute of Health and Medical Research)H-Index: 7
Last.Jean-Baptiste Michel (French Institute of Health and Medical Research)H-Index: 64
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Background: Since Red Blood Cells (RBCs) are the predominant cellular blood component interacting with the arterial wall we explored the role of RBCs efferocytosis by vascular smooth muscle cells (vSMCs) in the initiation of human atheroma. Methods and results: The comparison of human healthy aortas with aortic fatty streaks or fibroatheromas revealed that RBC angiophagy is implicated from the earliest stages of atherogenesis, as documented by the concomitant detection of redox-active iron, hemo...
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#1Richard Bayles (French Institute of Health and Medical Research)H-Index: 7
#2Sandrine Delbosc (French Institute of Health and Medical Research)H-Index: 14
Last.J.B. Michel (French Institute of Health and Medical Research)H-Index: 13
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#1Fanny PerezH-Index: 2
Last.Giuseppina Caligiuri (French Institute of Health and Medical Research)H-Index: 42
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Aims The presence of intravalve hemorrhage close to calcium crystals has recently been described in calcified aortic valves histologic slides. Those hemorrhages can play a pathogenic and initiating role in calcification process but they could also be a mere consequence of the mechanical damage due to calcifications. We aimed at assessing whether iron deposits are present both in calcified valves and non calcified valves. Methods and results Aortic valves deriving from patients operated at the Bi...
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#1Marc Clement (French Institute of Health and Medical Research)H-Index: 15
#2Kevin Guedj (French Institute of Health and Medical Research)H-Index: 7
Last.Antonino Nicoletti (French Institute of Health and Medical Research)H-Index: 39
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Tertiary lymphoid organs (TLOs), composed of B cell follicles, develop in the adventitia of atherosclerotic arteries. However, it is not known whether TLOs play an effective role in atherogenesis. In order to address this issue it is necessary to modulate the formation/function of these ectopic B cell follicles within the adventitia. Recent studies have shown that the function of germinal center B cells in secondary lymphoid organs (SLO) is tightly controlled by the Qa-1-restricted CD8+ T cells ...
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