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Ken-ichi Chikutei
Tokushima Bunri University
3Publications
2H-index
17Citations
Publications 3
Newest
Published on Sep 1, 2006in Environmental Toxicology and Pharmacology3.06
Aimi Kanada6
Estimated H-index: 6
(University of Tokushima),
Jun-ya Yamaguchi7
Estimated H-index: 7
(University of Tokushima)
+ 6 AuthorsYasuooyama30
Estimated H-index: 30
(University of Tokushima)
Abstract Tri- n -butyltin (TBT), one of environmental pollutants, disturbs intracellular Ca 2+ homeostasis by increasing intracellular Ca 2+ concentration ([Ca 2+ ] i ). Effect of TBT on oscillatory change in [Ca 2+ ] i (Ca 2+ oscillation) of rat thymocytes was examined using a laser microscope with fluo-3-AM in order to further elucidate the TBT toxicity related to intracellular Ca 2+ . The Ca 2+ oscillation was completely attenuated by 300 nM TBT. Since store-operated Ca 2+ channels are involv...
Published on Sep 1, 2006in Environmental Toxicology and Pharmacology3.06
Jun-ya Yamaguchi7
Estimated H-index: 7
(University of Tokushima),
Aimi Kanada6
Estimated H-index: 6
(University of Tokushima)
+ 7 AuthorsYasuooyama30
Estimated H-index: 30
(University of Tokushima)
Abstract We have previously reported that cremophor EL, a nonionic surfactant, at clinical concentrations significantly decreases the cell viability of rat thymocytes with phosphatidylserine-exposed (PS-exposed) membranes under in vitro condition. It is reminiscent of a possibility that sodium dodecylbenzenesulfonate (DCBS), an anionic surfactant world-widely used for detergents, also affects the cells in the similar manner. To test the possibility, the effect of DCBS on rat thymocytes has been ...
Published on Jul 1, 2006in European Journal of Pharmacology3.17
Ken-ichi Chikutei2
Estimated H-index: 2
(Tokushima Bunri University),
Tomohiro M. Oyama11
Estimated H-index: 11
(Tokushima Bunri University)
+ 7 AuthorsYasuooyama30
Estimated H-index: 30
(University of Tokushima)
Abstract Propofol (2,6-diisopropylphenol) is a general anesthetic possessing a neuroprotective action against oxidative stress produced by H 2 O 2 . H 2 O 2 induces an exposure of phosphatidylserine on outer surface of cell membranes, resulting in change in membrane phospholipid arrangement, in rat thymocytes. Since propofol is highly lipophilic, the agent is presumed to interact with membrane lipids and hence to modify the cell vulnerability to H 2 O 2 . Therefore, to test the possibility, we h...
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