Ken-ichi Chikutei
Tokushima Bunri University
ChemistryCell membraneCalciumViability assayIntracellular
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Publications 3
#1Aimi Kanada (University of Tokushima)H-Index: 6
#2Jun-ya Yamaguchi (University of Tokushima)H-Index: 7
Last. Yasuooyama (University of Tokushima)H-Index: 30
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Abstract Tri- n -butyltin (TBT), one of environmental pollutants, disturbs intracellular Ca 2+ homeostasis by increasing intracellular Ca 2+ concentration ([Ca 2+ ] i ). Effect of TBT on oscillatory change in [Ca 2+ ] i (Ca 2+ oscillation) of rat thymocytes was examined using a laser microscope with fluo-3-AM in order to further elucidate the TBT toxicity related to intracellular Ca 2+ . The Ca 2+ oscillation was completely attenuated by 300 nM TBT. Since store-operated Ca 2+ channels are involv...
1 CitationsSource
#1Jun-ya Yamaguchi (University of Tokushima)H-Index: 7
#2Aimi Kanada (University of Tokushima)H-Index: 6
Last. Yasuooyama (University of Tokushima)H-Index: 30
view all 10 authors...
Abstract We have previously reported that cremophor EL, a nonionic surfactant, at clinical concentrations significantly decreases the cell viability of rat thymocytes with phosphatidylserine-exposed (PS-exposed) membranes under in vitro condition. It is reminiscent of a possibility that sodium dodecylbenzenesulfonate (DCBS), an anionic surfactant world-widely used for detergents, also affects the cells in the similar manner. To test the possibility, the effect of DCBS on rat thymocytes has been ...
5 CitationsSource
#1Ken-ichi Chikutei (Tokushima Bunri University)H-Index: 2
#2Tomohiro M. Oyama (Tokushima Bunri University)H-Index: 11
Last. Yasuooyama (University of Tokushima)H-Index: 30
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Abstract Propofol (2,6-diisopropylphenol) is a general anesthetic possessing a neuroprotective action against oxidative stress produced by H 2 O 2 . H 2 O 2 induces an exposure of phosphatidylserine on outer surface of cell membranes, resulting in change in membrane phospholipid arrangement, in rat thymocytes. Since propofol is highly lipophilic, the agent is presumed to interact with membrane lipids and hence to modify the cell vulnerability to H 2 O 2 . Therefore, to test the possibility, we h...
12 CitationsSource