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Brendan Colón
University of Illinois at Urbana–Champaign
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#1Stephanie A. Flowers (UTHSC: University of Tennessee Health Science Center)H-Index: 2
#2Brendan Colón (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
Last.P. David Rogers (UTHSC: University of Tennessee Health Science Center)H-Index: 27
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In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed in clinical isolates, the specific contributions of individual ERG11 mutations to azole resistance in C. albicans have not been widely explored. We sequenced ERG11 in 63 fluconazole (FLC)-resistant cli...
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