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H. Toinét Cronjé
North-West University
SNPSingle-nucleotide polymorphismFibrinogenGeneticsBiology
2Publications
1H-index
3Citations
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Publications 2
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#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 16
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Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two novel and 12 known fibrinogen SNPs of potential functional relevance, in 2010 Tswana in...
1 CitationsSource
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 16
view all 7 authors...
Abstract Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes themselves. To this end we investigated s...
2 CitationsSource
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