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Ola Brønstad Brynildsrud
Norwegian Institute of Public Health
35Publications
12H-index
388Citations
Publications 35
Newest
#1Tuva Holt Jahr (NMBU: Norwegian University of Life Sciences)H-Index: 2
#2Marte Ragnhild Ekeland Fergestad (NMBU: Norwegian University of Life Sciences)H-Index: 1
Last.Ellen Skancke (NMBU: Norwegian University of Life Sciences)H-Index: 7
view all 5 authors...
Background Long-distance racing is known to cause alterations in haematological and serum biochemical parameters in sled dogs. Given that finishing status reflects the physical condition in dogs completing a race, such variations will mainly be the result of physiological adaption achieved during endurance exercise. However, changes observed in withdrawn dogs may indicate pathological conditions. The aim of this study was to reveal changes in haematological and serum biochemical values in sled d...
Genomes in living organisms consist of the nucleotides adenine (A), guanine (G), cytosine (C) and thymine (T). All prokaryotes have genomes consisting of double-stranded DNA, where the A's and G's (purines) of one strand bind respectively to the T's and C's (pyrimidines) of the other. As such, the number of A's on one strand nearly equals the number of T's on the other, and the same is true of one strand's G's and the other's C's. Globally, this relationship is formalized as Chargaff's first par...
#1Magnus Vikan Røsæg (NMBU: Norwegian University of Life Sciences)H-Index: 4
#2Åse Helen GarsethH-Index: 4
Last.Mona Dverdal JansenH-Index: 1
view all 4 authors...
Abstract Pancreas disease (PD), caused by several subtypes of salmonid alphavirus (SAV), is associated with significant economic losses in European salmonid aquaculture. In this retrospective cohort study, we investigate the impact of PD caused by SAV subtype 2 (SAV2) on growth, feed conversion, and mortality in farmed Atlantic salmon (Salmo salar L.). The study was based on harvest data from a large salmon farming company operating in the SAV2 endemic area of Norway. Mixed-effect regression ana...
#1Ola Brønstad Brynildsrud (FHI: Norwegian Institute of Public Health)H-Index: 12
#2Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Dominique A. Caugant (University of Oslo)H-Index: 54
view all 5 authors...
Neisseria meningitidis colonizes the human oropharynx and transmits mainly via asymptomatic carriage. Actual outbreaks of meningococcal meningitis are comparatively rare and occur when susceptible populations are exposed to hypervirulent clones, genetically distinct from the main carriage isolates. However, carriage isolates can evolve into pathogens through a limited number of recombination events. The present study examines the potential for the sequence type (ST)-192, by far the dominant clon...
#1Lucy van Dorp (UCL: University College London)H-Index: 9
#2Qi Wang (PKU: Peking University)H-Index: 19
Last.Hui Wang (PKU: Peking University)H-Index: 19
view all 15 authors...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly cause high-mortality outbreaks in hospital settings globally. Following a patient fatality at a hospital in Beijing due to a bla KPC-2-positive CRKP infection, close monitoring was put in place over the course of 14 months to characterize all bla KPC-2-positive CRKP in circulation in the hospital. Whole genome sequences were generated for 100 isolates from bla KPC-2-positive isolates from infected patients, carriers and the hospital ...
#1Nadav Topaz (National Center for Immunization and Respiratory Diseases)H-Index: 2
#2Dominique A. Caugant (University of Oslo)H-Index: 54
Last.Xin Wang (National Center for Immunization and Respiratory Diseases)H-Index: 16
view all 14 authors...
Abstract Background Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogroup A conjugate vaccine starting in 2010. We performed whole-genome sequencing on isolates collected post-2010 to assess their phylogenetic relationships and inter-country transmission. Methods A total of 716 invasive meningococcal isolates col...
#1Jon Bohlin (FHI: Norwegian Institute of Public Health)H-Index: 18
#2Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Kristian Alfsnes (FHI: Norwegian Institute of Public Health)H-Index: 4
view all 5 authors...
Background The purpose of the present study was to examine the GC content of substituted bases (sbGC) in the core genomes of 35 bacterial species. Each species, or core genome, constituted genomes from at least 10 strains. We also wanted to explore whether sbGC for each strain was associated with the corresponding species’ core genome GC content (cgGC). We present a simple mathematical model that estimates sbGC from cgGC. The model assumes only that the estimated sbGC is a function of cgGC propo...
#2Jon Bohlin (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Ernest A. Gould (AMU: Aix-Marseille University)H-Index: 55
view all 12 authors...
Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated tha...
#1Francois Balloux (UCL: University College London)H-Index: 56
#2Ola Brønstad Brynildsrud (FHI: Norwegian Institute of Public Health)H-Index: 12
Last.Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
view all 8 authors...
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of environmental sources of recurrent infections (e.g., contaminated sinks) and reconstruction of transmission chains (i.e., who infected whom) could help to reduce the incidence of nosoco...
#1Kristian AlfsnesH-Index: 4
#2Stephan A. Frye (Oslo University Hospital)H-Index: 21
Last.Ole Herman Ambur (Metropolitan University)H-Index: 9
view all 11 authors...
The spread of antibiotic resistance within and between different bacterial populations is a major health problem on a global scale. The identification of genetic transformation in genomic data from Neisseria meningitidis, the meningococcus (Mc), and other bacteria is problematic, since similar or even identical alleles may be involved. A particular challenge in naturally transformable bacteria generally is to distinguish between common ancestry and true recombined sites in sampled genome sequenc...
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