Gerald Grandl
ETH Zurich
Publications 11
#1Wenfei Sun (ETH Zurich)H-Index: 4
#2Hua Dong (ETH Zurich)H-Index: 4
Last.Gitalee Sarker (ETH Zurich)H-Index: 3
view all 10 authors...
In the version of this article originally published, the bars in the mean temperature graph in Fig. 1a were incorrectly aligned. The left-most bar should have been aligned with the Apr label on the projected month of conception axis. The error has been corrected in the print, PDF and HTML versions of this article.
#1Gerald GrandlH-Index: 4
#2Leon G. StraubH-Index: 5
Last.Christian WolfrumH-Index: 29
view all 7 authors...
KEY POINTS A ketogenic diet is known to lead to weight loss and is considered metabolically healthy; however there are conflicting reports on its effect on hepatic insulin sensitivity. KD fed animals appear metabolically healthy in the fasted state after 3 days of dietary challenge, whereas obesogenic high-fat diet (HFD) fed animals show elevated insulin levels. A glucose challenge reveals that both KD and HFD fed animals are glucose intolerant. Glucose intolerance correlates with increased lipi...
#1Wenfei Sun (ETH Zurich)H-Index: 4
#2Hua Dong (ETH Zurich)H-Index: 4
Last.Gitalee Sarker (ETH Zurich)H-Index: 3
view all 10 authors...
Recent research has focused on environmental effects that control tissue functionality and systemic metabolism. However, whether such stimuli affect human thermogenesis and body mass index (BMI) has not been explored. Here we show retrospectively that the presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans. In mice, we demonstrate that cold exposure (CE) of males, but not females, before mating results in improved systemic metabolism and protection fro...
Obesity and the metabolic syndrome (MS) are two of the pressing healthcare problems of our time. The MS is defined as increased abdominal obesity in concert with elevated fasting glucose levels, insulin resistance, elevated blood pressure, and plasma lipids. It is a key risk factor for type 2 diabetes mellitus (T2DM) and for cardiovascular complications and mortality. Here, we review work demonstrating that various aspects of coagulation and hemostasis, as well as vascular reactivity and functio...
#1Meenakshi Ravichandran (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Gerald GrandlH-Index: 4
Last.Michael Ristow (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 50
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The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
#1Gerald Grandl (ETH Zurich)H-Index: 4
#2Christian Wolfrum (ETH Zurich)H-Index: 29
Marrow adipose tissue (MAT) is a specialized adipose tissue with endocrine function found in bone marrow. In this issue of Cell Stem Cell , Ambrosi et al. (2017) identify a stem cell population in the bone marrow that can give rise to both osteogenic and adipogenic MAT precursors and is regulated by diet and aging and affects bone functionality.
#1Gerald Grandl (ETH Zurich)H-Index: 4
#2Sebastian Müller (ETH Zurich)H-Index: 10
Last.Christian Wolfrum (ETH Zurich)H-Index: 29
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Abstract Objective Adipose tissue shows a high degree of plasticity, and adipocyte hyperplasia is an important mechanism for adipose tissue expansion. Different adipose depots respond differently to an increased demand for lipid storage. Orchestrating cellular expansion in vivo requires extracellular matrix (ECM) remodeling and a high degree of interaction between cells and ECM. Methods We studied decellularized primary adipose stromal cell derived ECM of different adipose depots and reseeded th...
#1Susann Kumpf (ETH Zurich)H-Index: 2
#2Michael Mihlan (UDS: University of Strasbourg)H-Index: 12
Last.Arne Ittner (ETH Zurich)H-Index: 13
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Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the ...