Gerald Grandl
ETH Zurich
11Publications
4H-index
39Citations
Publications 11
Newest
Published on Sep 1, 2018in Nature Medicine 32.62
Wenfei Sun4
Estimated H-index: 4
(ETH Zurich),
Hua Dong4
Estimated H-index: 4
(ETH Zurich)
+ 19 AuthorsGitalee Sarker2
Estimated H-index: 2
(ETH Zurich)
Recent research has focused on environmental effects that control tissue functionality and systemic metabolism. However, whether such stimuli affect human thermogenesis and body mass index (BMI) has not been explored. Here we show retrospectively that the presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans. In mice, we demonstrate that cold exposure (CE) of males, but not females, before mating results in improved systemic metabolism and protection fro...
4 Citations Source Cite
Published on Feb 1, 2018in Seminars in Immunopathology 6.44
Gerald Grandl4
Estimated H-index: 4
(ETH Zurich),
Christian Wolfrum28
Estimated H-index: 28
(ETH Zurich)
Obesity and the metabolic syndrome (MS) are two of the pressing healthcare problems of our time. The MS is defined as increased abdominal obesity in concert with elevated fasting glucose levels, insulin resistance, elevated blood pressure, and plasma lipids. It is a key risk factor for type 2 diabetes mellitus (T2DM) and for cardiovascular complications and mortality. Here, we review work demonstrating that various aspects of coagulation and hemostasis, as well as vascular reactivity and functio...
10 Citations Source Cite
Published on Oct 1, 2018in The Journal of Physiology
Gerald Grandl4
Estimated H-index: 4
,
Leon G. Straub4
Estimated H-index: 4
+ 4 AuthorsChristian Wolfrum28
Estimated H-index: 28
KEY POINTS A ketogenic diet is known to lead to weight loss and is considered metabolically healthy; however there are conflicting reports on its effect on hepatic insulin sensitivity. KD fed animals appear metabolically healthy in the fasted state after 3 days of dietary challenge, whereas obesogenic high-fat diet (HFD) fed animals show elevated insulin levels. A glucose challenge reveals that both KD and HFD fed animals are glucose intolerant. Glucose intolerance correlates with increased lipi...
3 Citations Source Cite
Published on Nov 1, 2018in Nature Medicine 32.62
Wenfei Sun4
Estimated H-index: 4
(ETH Zurich),
Hua Dong4
Estimated H-index: 4
(ETH Zurich)
+ 19 AuthorsGitalee Sarker2
Estimated H-index: 2
(ETH Zurich)
In the version of this article originally published, the bars in the mean temperature graph in Fig. 1a were incorrectly aligned. The left-most bar should have been aligned with the Apr label on the projected month of conception axis. The error has been corrected in the print, PDF and HTML versions of this article.
Source Cite
Published on Jun 1, 2017in Cell Stem Cell 23.29
Gerald Grandl4
Estimated H-index: 4
(ETH Zurich),
Christian Wolfrum28
Estimated H-index: 28
(ETH Zurich)
Marrow adipose tissue (MAT) is a specialized adipose tissue with endocrine function found in bone marrow. In this issue of Cell Stem Cell , Ambrosi et al. (2017) identify a stem cell population in the bone marrow that can give rise to both osteogenic and adipogenic MAT precursors and is regulated by diet and aging and affects bone functionality.
1 Citations Source Cite
Published on Oct 1, 2017in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Gerald Grandl4
Estimated H-index: 4
,
Michael Ristow47
Estimated H-index: 47
(École Polytechnique Fédérale de Lausanne)
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
1 Citations Source Cite
Published on Oct 1, 2016in Molecular metabolism 6.29
Gerald Grandl4
Estimated H-index: 4
(ETH Zurich),
Sebastian Müller10
Estimated H-index: 10
(ETH Zurich)
+ 3 AuthorsChristian Wolfrum28
Estimated H-index: 28
(ETH Zurich)
Abstract Objective Adipose tissue shows a high degree of plasticity, and adipocyte hyperplasia is an important mechanism for adipose tissue expansion. Different adipose depots respond differently to an increased demand for lipid storage. Orchestrating cellular expansion in vivo requires extracellular matrix (ECM) remodeling and a high degree of interaction between cells and ECM. Methods We studied decellularized primary adipose stromal cell derived ECM of different adipose depots and reseeded th...
9 Citations Source Cite
Published on Nov 6, 2012in EMBO Reports 8.75
Susann Kumpf2
Estimated H-index: 2
(ETH Zurich),
Michael Mihlan12
Estimated H-index: 12
(University of Strasbourg)
+ 10 AuthorsArne Ittner12
Estimated H-index: 12
(ETH Zurich)
Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the ...
4 Citations Source Cite
Published on Jan 1, 2011in Journal of Biological Engineering 5.26
Buz Barstow7
Estimated H-index: 7
(Harvard University),
Christina M. Agapakis12
Estimated H-index: 12
(Harvard University)
+ 3 AuthorsEdwin H Wintermute5
Estimated H-index: 5
(Harvard University)
Background FeFe-hydrogenases are the most active class of H2-producing enzymes known in nature and may have important applications in clean H2 energy production. Many potential uses are currently complicated by a crucial weakness: the active sites of all known FeFe-hydrogenases are irreversibly inactivated by O2.
7 Citations Source Cite
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