R Thomas Lumbers
University College London
Publications 6
#1R Thomas LumbersH-Index: 3
#2Nicole Martin (UCL: University College London)H-Index: 5
Last.L Ceri Davies (St Bartholomew's Hospital)H-Index: 1
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Approximately half of all patients with heart failure have preserved left ventricular ejection fraction (LVEF), yet in contrast to heart failure with reduced ejection fraction (HFrEF), no treatments have yet been shown to be effective at improving outcomes.1 Neurohumoral activation is observed in heart failure across the full spectrum of left ventricular function2; however, pharmacological inhibition of the renin–angiotensin aldosterone system (RAAS) has only been shown to improve survival and r...
#1Sonia Shah (UCL: University College London)H-Index: 36
#2Albert Henry (UCL: University College London)
Last.R Thomas Lumbers (UCL: University College London)H-Index: 3
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Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent associations with HF at 11 genomic loci, all of which demonstrate on...
#1Valerie KuanH-Index: 2
#2Spiros Denaxas (UCL: University College London)H-Index: 23
Last.Aroon Hingorani (UCL: University College London)H-Index: 72
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Summary Background To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know which sections of the population are susceptible to which health conditions and at which ages. Hence, we aimed to map the course of human health by identifying the 50 most common health conditions in each decade of life and estimating the median age at first diagnosis. Methods We developed phenotyping algorithms and code...
#1R Thomas Lumbers (UCL: University College London)H-Index: 3
#2Nicole Martin (UCL: University College London)H-Index: 5
Last.Ceri Davies (London Chest Hospital)H-Index: 8
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This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the safety and efficacy of beta-blockers (BBs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor antagonists (ARBs), mineralocorticoid receptor antagonists (MRAs), and angiotensin receptor neprilysin inhibitors (ARNIs) for the treatment of patients with heart failure (HF) with preserved ejection fraction (HFpEF).
#1Chris Finan (UCL: University College London)H-Index: 12
#2Anna Gaulton (EMBL-EBI: European Bioinformatics Institute)H-Index: 23
Last.Juan P. Casas (UCL: University College London)H-Index: 69
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Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease biomarkers and disease end points) are important steps in drug development. Clinically relevant associations of variants in genes encoding drug targets model the effect of modifying the same targets pharmacologically. To delineate drug development (including repurposing) opportunities arising from this paradigm, we connected complex disease- ...