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Mehran Ganji
University of California, San Diego
11Publications
4H-index
59Citations
Publications 11
Newest
#1Angelique C. Paulk (Harvard University)H-Index: 16
#2Jae-Hyun Yang (Harvard University)H-Index: 1
Last.Sydney S. Cash (Harvard University)H-Index: 46
view all 29 authors...
Efforts to deepen our understanding of the nervous system depends on high resolution sampling of neuronal activity. We leveraged clinically necessary intracranial monitoring performed during surgical resections to record from the cortical surface (N=30) using high spatial resolution, low impedance PEDOT:PSS microelectrodes. We identified three classes of activity. The first included relatively fast repeated waveforms with kinetics similar to, but not perfectly matching, extracellular single unit...
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#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
#2Angelique C. Paulk (Harvard University)H-Index: 16
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 25 authors...
The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibil...
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#1Nicholas Rogers (UCSD: University of California, San Diego)H-Index: 1
#2John Hermiz (UCSD: University of California, San Diego)H-Index: 3
Last.Vikash Gilja (UCSD: University of California, San Diego)H-Index: 24
view all 14 authors...
Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated micr...
1 CitationsSource
#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
#2Lorraine Hossain (UCSD: University of California, San Diego)H-Index: 1
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 8 authors...
1 CitationsSource
#1John Hermiz (UCSD: University of California, San Diego)H-Index: 3
#2Nicholas Rogers (UCSD: University of California, San Diego)H-Index: 1
Last.Vikash Gilja (UCSD: University of California, San Diego)H-Index: 24
view all 10 authors...
Abstract Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment of neurological disorders. Recent advances in device engineering are poised to enable orders of magnitude increase in the resolution of ECoG without comprised measurement qu...
4 CitationsSource
#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
#2Erik Kaestner (UCSD: University of California, San Diego)H-Index: 5
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 18 authors...
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based inte...
16 CitationsSource
#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
#2Ahmed T. Elthakeb (UCSD: University of California, San Diego)H-Index: 4
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 6 authors...
Reduced contact size would permit higher resolution cortical recordings, but the effects of diameter on crucial recording and stimulation properties are poorly understood. Here, the first systematic study of scaling effects on the electrochemical properties of metallic Pt and Au and organic poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) electrodes is presented. PEDOT:PSS exhibits better faradaic charge transfer and capacitive charge coupling than metal electrodes, and these c...
4 CitationsSource
#1Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
#2Atsunori Tanaka (UCSD: University of California, San Diego)H-Index: 6
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 5 authors...
The efficacy of electrical brain stimulation in combatting neurodegenerative diseases and initiating function is expected to be significantly enhanced with the development of smaller scale microstimulation electrodes and refined stimulation protocols. These benefits cannot be realized without a thorough understanding of scaling effects on electrochemical charge injection characteristics. This study fabricates and characterizes the electrochemical stimulation capabilities of Au, Pt, poly(3,4-ethy...
10 CitationsSource
#1Keundong Lee (SNU: Seoul National University)H-Index: 5
#2Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
Last.Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 32
view all 10 authors...
Electrocorticography (ECoG) is a powerful tool for direct mapping of local field potentials from the brain surface. Progress in development of high-fidelity materials such as poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) on thin conformal substrates such as parylene C enabled intimate contact with cortical surfaces and higher quality recordings from small volumes of neurons. Meanwhile, stimulation of neuronal activity is conventionally accomplished with electrical microstim...
1 CitationsSource
#1Ilke Uguz ('ENS Paris': École Normale Supérieure)H-Index: 9
#2Mehran Ganji (UCSD: University of California, San Diego)H-Index: 4
Last.George G. Malliaras ('ENS Paris': École Normale Supérieure)H-Index: 70
view all 12 authors...
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
18 CitationsSource
12