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Sophie E.A. Akkermans
Radboud University Nijmegen
15Publications
4H-index
67Citations
Publications 17
Newest
#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Natalie J. Forde (Radboud University Nijmegen)H-Index: 5
Last.Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
view all 7 authors...
Abstract Findings of executive functioning deficits in Tourette syndrome (TS) have so far been inconsistent, possibly due to methodological challenges of previous studies, such as the use of small sample sizes and not accounting for comorbid attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or medication use. We aimed to address these issues by examining several areas of executive functioning (response inhibition, attentional flexibility, cognitive control, an...
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#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Jan-Bernard C. Marsman (UMCG: University Medical Center Groningen)H-Index: 10
Last.Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 9 authors...
Abstract Little is known about the brain’s functional organization during resting-state in children with Tourette syndrome (TS). We aimed to investigate this with a specific focus on the role of comorbid attention-deficit/hyperactivity disorder (ADHD). We applied graph theoretical analysis to resting-state functional magnetic resonance imaging data of 109 8-to-12-year-old children with TS (n=46), ADHD without tics (n=23), and healthy controls (n=40). First, we compared these three groups, and in...
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#1Renata B. Cupertino (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
Last.Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 20 authors...
Neuroimaging studies have associated Attention-Deficit/Hyperactivity Disorder (ADHD) with altered brain anatomy. However, small and heterogeneous study samples, and the use of region-of-interest and tissue-specific analyses have limited the consistency and replicability of these effects. The present study uses a fully data-driven multivariate approach to investigate alterations in both gray and white matter simultaneously, and capture neuroanatomical features associated with ADHD in two large, i...
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#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2N. Rheinheimer (Radboud University Nijmegen)H-Index: 1
Last.Philippe AubyH-Index: 1
view all 24 authors...
1 CitationsSource
#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 12
Last.Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 9 authors...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mea...
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#1Christienne G. Damatac (Radboud University Nijmegen)H-Index: 3
#2Marcel P. Zwiers (Radboud University Nijmegen)H-Index: 38
Last.Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 13 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter microstructure, measured by diffusion-weighted imaging (DWI) and quantified by fractional anisotropy (FA). In the largest DWI analysis of ADHD to date, we systematically investigated if FA is associated with: current and lifetime diagnosis, categorical diagnosis and continuo...
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#1Natalie J. FordeH-Index: 5
#2Jilly NaaijenH-Index: 6
Last.Pieter J. HoekstraH-Index: 40
view all 8 authors...
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#1Natalie J. Forde (Radboud University Nijmegen)H-Index: 5
#2Jilly Naaijen (Radboud University Nijmegen)H-Index: 6
Last.Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 9 authors...
Abstract Multi-modal imaging may improve our understanding of the relationship between cortical morphology and cytoarchitecture. To this end we integrated the analyses of several magnetic resonance imaging (MRI) and spectroscopy (MRS) metrics within the anterior cingulate cortex (ACC). Considering the ACCs role in neurodevelopmental disorders, we also investigated the association between neuropsychiatric symptoms and the various metrics. T1 and diffusion-weighted MRI and 1H-MRS (ACC voxel) data ...
3 CitationsSource
#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2Maartje Luijten (Radboud University Nijmegen)H-Index: 18
Last.Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 5 authors...
The putamen has been shown to play a key role in inhibitory control and addiction, and consists of distinct subregions associated with distinct functions. The anterior putamen is thought to be specialized in goal-directed control or response-monitoring in connection with frontal regions, whereas the posterior part is specialized in habitual or automatic responding in connection with sensorimotor regions. The present study is the first to delineate functional networks of the anterior and posterio...
4 CitationsSource
#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 12
Last.Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 8 authors...
Smoking rates are particularly high during adolescence and young adulthood, when the brain is still undergoing significant developmental changes. Cross-sectional studies have revealed altered brain structure in smokers, such as thinner frontal cortical areas. Attention-deficit/hyperactivity disorder (ADHD) increases the risk of becoming nicotine-dependent, and has also been associated with abnormalities in frontal gray matter structure. The present study examines the relationships between smokin...
2 CitationsSource
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