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Thomas Rousselle
University of Mississippi Medical Center
16Publications
5H-index
67Citations
Publications 16
Newest
#1Ahmed A. Mohsin (VCU: Virginia Commonwealth University)H-Index: 1
#2Qun Chen (VCU: Virginia Commonwealth University)H-Index: 31
Last.Edward J. Lesnefsky (VCU: Virginia Commonwealth University)H-Index: 17
view all 10 authors...
Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of metformin in cultured cells and mouse hearts via the novel mechanism of acute downregulation of complex I. The effect of high dose of metformin on complex I activity was studied in isolated heart mitochondria and cultured H9c2 cells. Protection with metformin was evaluated in H9c2 cells at reoxygenation and at early reperfusion in isolated per...
#1Qingguo Lu (Sichuan University)H-Index: 1
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injur...
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ...
#1Xu Chen (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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Abstract Background AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that protects against cardiomyocyte injury during ischemia and reperfusion. c-Jun N-terminal kinase (JNK), a mitogen activated protein kinase, is activated by ischemia and reperfusion. NF-κB is an important transcription factor involved in ischemia and reperfusion injury. Methods and Results The intrinsic activation of AMPK attenuates the inflammation which occurred during ischemia/reperfusion through the modula...
#1Lin Wang (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
#2Thomas RousselleH-Index: 5
Last.Ji LiH-Index: 11
view all 3 authors...
Ischemic tolerance of heart decreases with age. Caloric restriction (CR) is the most reliable intervention to extend lifespan and prevent age-related disorders. We have revealed that both AMPK and SIRT1 signaling pathways are involved in the impairments occurred in aged hearts. We hypothesize that cardiac AMPK-SIRT1 signaling cascade mediates the increased tolerance of aged heart to ischemic insults by caloric restriction. Aged (18-20 months) mice were divided into 2 groups: al libitum (AL) food...
#1Courtney Cates (UMMC: University of Mississippi Medical Center)H-Index: 9
#2Thomas Rousselle (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
Abstract We found that the anticoagulant plasma protease, activated protein C (APC), stimulates the energy sensor kinase, AMPK, in the stressed heart by activating protease-activated receptor 1 (PAR1) on cardiomyocytes. Wild-type (WT) and AMPK-kinase dead (KD) transgenic mice were subjected to transverse aortic constriction (TAC) surgery. The results demonstrated that while no phenotypic differences can be observed between WT and AMPK-KD mice under normal physiological conditions, AMPK-KD mice e...
#1Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Lin Wang (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Abstract We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the heart in response to ischemic stress. The objective of this study is to determine whether Sestrin2-AMPK complex modulates PGC-1α in the heart and protects the heart from ischemic insults. In order to characterize the role of cardiac Sestrin2-AMPK signaling cascade in aging, C57BL/6 wild type young mice (3–4 m...
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