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Asli D. Yıldırım
Bilkent University
Publications 2
Published in Molecular metabolism 6.18
Ismail Cimen (LMU: Ludwig Maximilian University of Munich), Zehra Yildirim + -3 AuthorsEbru Erbay11
Estimated H-index: 11
Abstract Objective Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can worsen dyslipidemia, but recent epidemiological studies show full-fat dairy consumption may reduce diabetes and CVD risk. This dairy paradox prompted a reassessment of the dietary guidelines. The beneficial metabolic effects in dairy have been claimed for a ruminant-derive...
Published on Mar 1, 2019in Journal of the American College of Cardiology 18.64
Umut I. Onat2
Estimated H-index: 2
(Bilkent University),
Asli D. Yıldırım2
Estimated H-index: 2
+ 11 AuthorsJon Sin7
Estimated H-index: 7
(Cedars-Sinai Medical Center)
Abstract Background Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step in translational control and must be tightly regulated; however, persistent eIF2α phosphorylation is observed in mouse and human atheroma. Objectives Potent ISR inhibitors that modulate neurodegenerative disorders have been identified. Here, the authors evaluated the pot...
Published on Sep 28, 2016in Science Translational Medicine 17.16
Ismail Çimen2
Estimated H-index: 2
(Bilkent University),
Begüm Kocatürk2
Estimated H-index: 2
(Bilkent University)
+ 10 AuthorsUyen T. T. Nguyen11
Estimated H-index: 11
Although fatty foods often have a bad reputation when it comes to atherosclerosis, a study by Cimen et al . identifies a type of fat that is not only harmless but also protective. Palmitoleate is a lipid that can be produced directly by the human body and is also found in a variety of foods, but only in small amounts. Using human cells and mouse models, the authors demonstrate that palmitoleate reduces metabolic stress in a variety of tissues as well as in atherosclerotic plaques and thus decrea...