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Bugra Ayan
Pennsylvania State University
Biomedical engineeringNanotechnologyMaterials science3D bioprintingBiofabrication
11Publications
5H-index
187Citations
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Publications 13
Newest
#1Dong Nyoung Heo (Kyung Hee University)H-Index: 18
Last. Ibrahim T. OzbolatH-Index: 25
view all 8 authors...
Extrusion-based bioprinting of hydrogels in a granular secondary gel enables the fabrication of cell-laden three-dimensional (3D) constructs in an anatomically accurate manner, which is challenging using conventional extrusion-based bioprinting processes. In this study, carbohydrazide-modified gelatin (Gel-CDH) was synthesized and deposited into a new multi-functional support bath consisting of gelatin microparticles suspended in oxidized alginate (OAlg) solution. During extrusion, Gel-CDH and O...
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#1Bugra Ayan (PSU: Pennsylvania State University)H-Index: 5
#2Dong Nyoung Heo (Kyung Hee University)H-Index: 18
Last. Ibrahim T. OzbolatH-Index: 25
view all 7 authors...
Three-dimensional (3D) bioprinting is an appealing approach for building tissues; however, bioprinting of mini-tissue blocks (i.e., spheroids) with precise control on their positioning in 3D space has been a major obstacle. Here, we unveil “aspiration-assisted bioprinting (AAB),” which enables picking and bioprinting biologics in 3D through harnessing the power of aspiration forces, and when coupled with microvalve bioprinting, it facilitated different biofabrication schemes including scaffold-b...
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#1Veli Ozbolat (Çukurova University)H-Index: 7
#2Madhuri Dey (PSU: Pennsylvania State University)H-Index: 6
Last. Ibrahim T. OzbolatH-Index: 25
view all 4 authors...
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#1Aishwarya Satpathy (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 1
#2Pallab Datta (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 12
Last. Ibrahim T. OzbolatH-Index: 25
view all 6 authors...
ABSTRACTIntroduction: Although there have been significant contributions from the pharmaceutical industry to clinical practice, several diseases remain unconquered, with the discovery of new drugs ...
2 CitationsSource
#1Monika Hospodiuk (PSU: Pennsylvania State University)H-Index: 5
#2Madhuri Dey (PSU: Pennsylvania State University)H-Index: 6
Last. Ibrahim T. OzbolatH-Index: 25
view all 7 authors...
Despite the recent achievements in cell-based therapies for curing type-1 diabetes (T1D), capillarization in beta (β)-cell clusters is still a major roadblock as it is essential for long-term viability and function of β-cells in vivo. In this research, we report sprouting angiogenesis in engineered pseudo islets (EPIs) made of mouse insulinoma βTC3 cells and rat heart microvascular endothelial cells (RHMVECs). Upon culturing in three-dimensional (3D) constructs under angiogenic conditions, EPIs ...
5 CitationsSource
#1Veli Ozbolat (Çukurova University)H-Index: 7
#2Madhuri Dey (PSU: Pennsylvania State University)H-Index: 6
Last. Ibrahim T. OzbolatH-Index: 25
view all 6 authors...
Despite extensive use of polydimethylsiloxane (PDMS) in medical applications, such as lab-on-a-chip or tissue/organ-on-a-chip devices, point-of-care devices, and biological machines, the manufacturing of PDMS devices is limited to soft-lithography and its derivatives, which prohibits the fabrication of geometrically complex shapes. With the recent advances in three-dimensional (3D) printing, use of PDMS for fabrication of such complex shapes has gained considerable interest. This research presen...
14 CitationsSource
#1Ashley N. Leberfinger (PSU: Pennsylvania State University)H-Index: 5
#2Monika Hospodiuk (PSU: Pennsylvania State University)H-Index: 5
Last. Dino J. RavnicH-Index: 14
view all 9 authors...
2 CitationsSource
#1Weijie Peng (PSU: Pennsylvania State University)H-Index: 4
#2Pallab Datta (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 12
Last. Ibrahim T. Ozbolat (PSU: Pennsylvania State University)H-Index: 25
view all 7 authors...
Three-dimensional (3D) organoids have shown advantages in cell culture over traditional two-dimensional (2D) culture, and have great potential in various applications of tissue engineering. However, there are limitations in current organoid fabrication technologies, such as uncontrolled size, poor reproductively, and inadequate complexity of organoids. In this chapter, we present the existing techniques and discuss the major challenges for 3D organoid biofabrication. Future perspectives on organ...
4 CitationsSource
#1Pallab DattaH-Index: 12
#2Veli OzbolatH-Index: 7
Last. Ibrahim T. OzbolatH-Index: 25
view all 5 authors...
Craniofacial (CF) tissue is an architecturally complex tissue consisting of both bone and soft tissues with significant patient specific variations. Conditions of congenital abnormalities, tumor resection surgeries, and traumatic injuries of the CF skeleton can result in major deficits of bone tissue. Despite advances in surgical reconstruction techniques, management of CF osseous deficits remains a challenge. Due its inherent versatility, bioprinting offers a promising solution to address these...
8 CitationsSource
#1Weijie Peng (PSU: Pennsylvania State University)H-Index: 4
#2Pallab Datta (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 12
Last. Ibrahim T. OzbolatH-Index: 25
view all 6 authors...
Abstract Successful launch of a commercial drug requires significant investment of time and financial resources wherein late-stage failures become a reason for catastrophic failures in drug discovery. This calls for infusing constant innovations in technologies, which can give reliable prediction of efficacy, and more importantly, toxicology of the compound early in the drug discovery process before clinical trials. Though computational advances have resulted in more rationale in silico designin...
44 CitationsSource
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