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Alexander J. Hish
Duke University
8Publications
3H-index
41Citations
Publications 8
Newest
#1Mohit Kumar Jolly (Rice University)H-Index: 20
#2Kathryn E. Ware (Rice University)H-Index: 6
Last.Alexander J. Hish (Duke University)H-Index: 3
view all 23 authors...
CDH1 (also known as E-cadherin), an epithelial-specific cell–cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, and mediating intracellular signaling. Downregulation of E-cadherin is a hallmark of epithelial-to-mesenchymal transition (EMT) and correlates with poor prognosis in multiple carcinomas. Conversely, upregulation of E-cadherin is prognostic for improved survival in sarcomas. Yet, despite the prognostic benefit of E-cadherin...
#1Gabriela A. Nagy (Duke University)
#2Caitlin M. Fang (Duke University)H-Index: 4
Last.M. Zachary Rosenthal (Duke University)H-Index: 24
view all 7 authors...
#1Mohit Kumar Jolly (Rice University)H-Index: 20
#2Kathryn E. Ware (Duke University)H-Index: 6
Last.Suzanne Bartholf DeWitt (Duke University)H-Index: 4
view all 21 authors...
E-cadherin, an epithelial-specific cell-cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, and mediating intracellular signaling. Downregulation of E-cadherin is a hallmark of epithelial-mesenchymal transition (EMT) and correlates with poor prognosis in multiple carcinomas. Conversely, upregulation of E-cadherin is prognostic for improved survival in sarcomas. Yet, despite the prognostic benefit of E-cadherin expression in sarcoma, ...
#1Kathryn E. WareH-Index: 6
#2Shivee GiljaH-Index: 2
Last.William C. EwardH-Index: 15
view all 13 authors...
Phenotypic plasticity refers to a phenomenon in which cells transiently gain traits of another lineage. During carcinoma progression, phenotypic plasticity drives invasion, dissemination and metastasis. Indeed, while most of the studies of phenotypic plasticity have been in the context of epithelial-derived carcinomas, it turns out sarcomas, which are mesenchymal in origin, also exhibit phenotypic plasticity, with a subset of sarcomas undergoing a phenomenon that resembles a mesenchymal-epitheli...
#1Brenda Manzano-Winkler (Duke University)H-Index: 3
#2Alexander J. Hish (Duke University)H-Index: 3
Last.Mohamed A. F. Noor (Duke University)H-Index: 43
view all 4 authors...
While females often reject courtship attempts by heterospecific males, reproductive interference by harassment from such males can nonetheless occur, potentially reducing female fitness. Such effects may be profound following a range expansion, when males from a new species may suddenly encounter (and perhaps even become abundant relative to) females of related native species. Drosophila subobscura recently invaded North America and may impact native species through reproductive interference and...
#1Jason A. Somarelli (Duke University)H-Index: 13
#2Daneen Schaeffer (Duke University)H-Index: 9
Last.Jonathan I. Epstein (Johns Hopkins University)H-Index: 123
view all 13 authors...
The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial–mesenchymal and mesenchymal–epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whethe...
#1Jennifer N. Gredler (Duke University)H-Index: 1
#2Alexander J. Hish (Duke University)H-Index: 3
Last.Mohamed A. F. Noor (Duke University)H-Index: 43
view all 3 authors...
Many molecular ecological and evolutionary studies sample wild populations at a single point in time, but that data represents genetic variation from a potentially unrepresentative snapshot in time. Variation across time in genetic parameters may occur quickly in species that produce multiple generations of offspring per year. Here, we compare genetic diversity in wild caught populations of Drosophila persimilis and Drosophila pseudoobscura collected 16 years apart at the same time of year and s...
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