Krishna M. Sinha
University of Texas MD Anderson Cancer Center
Publications 40
#1Krishna M. SinhaH-Index: 18
Last.Johnny HuardH-Index: 90
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#1Krishna M. Sinha (University of Texas Health Science Center at Houston)H-Index: 18
#2Rozita Bagheri-Yarmand (University of Texas MD Anderson Cancer Center)H-Index: 18
Last.Johnny Huard (University of Texas Health Science Center at Houston)H-Index: 90
view all 13 authors...
Epigenetic changes that cause dysregulated gene expression during progression of androgen-independent prostate cancer (PCa) and metastatic skeletal lesions remain elusive. Here, we explored the role of histone demethylase NO66 in the pathogenesis of PCa and bone metastasis-related skeletal lesions. Tissue and cDNA microarrays of PCa were analyzed for NO66 mRNA and protein levels. We examined the effects of gain and loss of NO66 function on cell viability, colony formation, migration, invasion, a...
#1Kasi ManikandanH-Index: 2
#2Deepika Prasad (IISc: Indian Institute of Science)H-Index: 1
Last.Krishna M. SinhaH-Index: 18
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Cyclic di-GMP and cyclic di-AMP are second messengers produced by a wide variety of bacteria. They influence bacterial cell survival, biofilm formation, virulence and bacteria-host interactions. However, many of their cellular targets and biological effects are yet to be determined. A chemical proteomics approach revealed that Mycobacterium smegmatis RecA (MsRecA) possesses a high-affinity cyclic di-AMP binding activity. We further demonstrate that both cyclic di-AMP and cyclic di-GMP bind speci...
2 CitationsSource
#1Ji-Myung BaeH-Index: 1
#2John C. ClarkeH-Index: 3
Last.Amjad JavedH-Index: 46
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7 CitationsSource
#1Thomas Garcia (UH: University of Houston)H-Index: 9
#2Parag Anil ParekhH-Index: 11
Last.Marie Claude HofmannH-Index: 33
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In the seminiferous epithelium of the testis, Sertoli cells are key niche cells directing proliferation and differentiation of spermatogonial stem cells (SSCs) into spermatozoa. Sertoli cells produce glial cell line-derived neurotrophic factor (GDNF), which is essential for SSC self-renewal and progenitor expansion. While the role of GDNF in the testis stem cell niche is established, little is known about how this factor is regulated. Our previous studies on NOTCH activity in Sertoli cells demon...
12 CitationsSource
#1Qin Chen (University of Texas at Austin)H-Index: 3
#2Krishna M. Sinha (University of Texas at Austin)H-Index: 18
Last.Benoit de Crombrugghe (University of Texas at Austin)H-Index: 8
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Our previous studies indicated that the Jumonji C (JmjC)-domain-containing NO66 is a histone demethylase with specificity for methylated histone H3K4 and H3K36. NO66 binds to the transcription factor Osterix (Osx) and inhibits its transcriptional activity in promoter assays. However, the physiological role of NO66 in formation of mammalian bones is unknown. Here, using a genetically engineered mouse model, we show that during early skeletal development, Prx1-Cre dependent mesenchymal deletion of...
8 CitationsSource
Abstract The RET proto-oncogene, a tyrosine kinase receptor, is widely known for its essential role in cell survival. Germ line missense mutations, which give rise to constitutively active oncogenic RET, were found to cause multiple endocrine neoplasia type 2, a dominant inherited cancer syndrome that affects neuroendocrine organs. However, the mechanisms by which RET promotes cell survival and prevents cell death remain elusive. We demonstrate that in addition to cytoplasmic localization, RET i...
17 CitationsSource
#1Minhao WuH-Index: 8
#2Yue TaoH-Index: 4
Last.Jianye ZangH-Index: 15
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#1John C. Clarke (UA: University of Alabama)H-Index: 3
#2Ji Myung Bae (Wonkwang University)H-Index: 1
Last.Amjad Javed (UA: University of Alabama)H-Index: 46
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AbstractTooth formation is a multifaceted process involving numerous interactions between oral epithelium and neural crest derived ecto-mesenchyme from morphogenesis to cyto-differentiation. The precise molecular regulator that drives the cyto-differentiation and dynamic cross-talk between the two cell types has yet to be fully understood. Runx2 along with its downstream target Sp7 are essential transcription factors for development of the mineralizing cell types. Global knockout of the Runx2 ge...
3 CitationsSource