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Amelie Derenne
University of Coimbra
Permeability (electromagnetism)BioavailabilityDextranInsulinIntestinal permeability
1Publications
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#1Marlene Lopes (UC: University of Coimbra)H-Index: 6
#2Amelie Derenne (UC: University of Coimbra)H-Index: 1
Last. António J. Ribeiro (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 28
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Although the oral administration of insulin is recognized as the safest and most attractive, insulin oral bioavailability is usually reduced due to the susceptibility to acidic and enzymatic degradation in the gastrointestinal (GI) tract and intrinsic low intestinal permeability. Nanoencapsulation of insulin is, thus, foreseen as a promising approach to overcome most of these drawbacks. The effect of the GI environment on the aggregation of alginate/dextran sulfate-based nanometric-sized particl...
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