Yanick Hagemeijer
University Medical Center Groningen
Publications 15
#1P S de Vries (University of Texas Health Science Center at Houston)H-Index: 3
#2Michael R. Brown (University of Texas Health Science Center at Houston)H-Index: 6
Last.Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 264 authors...
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394...
6 CitationsSource
#1Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
#2Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
Last.L. Adrienne CupplesH-Index: 137
view all 299 authors...
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. ...
7 CitationsSource
#1Paul S. de VriesH-Index: 15
#2Michael R. BrownH-Index: 6
Last.Alanna C. MorrisonH-Index: 44
view all 266 authors...
#1Mary F. Feitosa (WashU: Washington University in St. Louis)H-Index: 49
#2Aldi T. Kraja (WashU: Washington University in St. Louis)H-Index: 25
Last.Douglas E. Levy (NIH: National Institutes of Health)H-Index: 200
view all 272 authors...
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucl...
185 CitationsSource
#1Niek Verweij (UMCG: University Medical Center Groningen)H-Index: 37
#2Ruben N. Eppinga (UMCG: University Medical Center Groningen)H-Index: 7
Last.Diana van Heemst (UMCG: University Medical Center Groningen)H-Index: 83
view all 4 authors...
Coronary artery disease (CAD) is the major cause of morbidity and mortality in the world. Identification of novel genetic determinants may provide new opportunities for developing innovative strategies to predict, prevent and treat CAD. Therefore, we meta-analyzed independent genetic variants passing P <× 10−5 in CARDIoGRAMplusC4D with novel data made available by UK Biobank. Of the 161 genetic variants studied, 71 reached genome wide significance (p < 5 × 10−8) including 15 novel loci. These no...
29 CitationsSource
Telomeres are DNA repeat structures with protein complexes capping the ends of chromosomes important for chromosomal stability and cellular integrity [(1)][1]. Telomeres shorten with each cell division and under environmental conditions such as oxidative stress. Therefore, telomere length (TL) has
7 CitationsSource
#1Marten E. van den Berg (EUR: Erasmus University Rotterdam)H-Index: 9
#2Helen R. Warren (QMUL: Queen Mary University of London)H-Index: 20
Last.Patricia B. Munroe (QMUL: Queen Mary University of London)H-Index: 74
view all 121 authors...
Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses. Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association resu...
9 CitationsSource
#1Ingrid E. Christophersen (Broad Institute)H-Index: 13
#2Michiel Rienstra (UG: University of Groningen)H-Index: 37
Last.Patrick T. Ellinor (Broad Institute)H-Index: 72
view all 162 authors...
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,...
97 CitationsSource
#1M. Yldau van der Ende (UMCG: University Medical Center Groningen)H-Index: 4
#2Minke H. T. Hartman (UMCG: University Medical Center Groningen)H-Index: 5
Last.Diana van Heemst (UMCG: University Medical Center Groningen)H-Index: 83
view all 11 authors...
Abstract Background The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. Methods and results Baseline cardiovascular phenotypes were defined in 9700 juvenile (8–18years) and 15...
48 CitationsSource