Yanick Hagemeijer
University Medical Center Groningen
Publications 13
Published on Jan 29, 2019in American Journal of Epidemiology4.47
P. de Vries11
Estimated H-index: 11
(University of Texas Health Science Center at Houston),
P S de Vries2
Estimated H-index: 2
(University of Texas Health Science Center at Houston)
+ 261 AuthorsXiaosen Guo55
Estimated H-index: 55
(UCLA Medical Center)
Published on Apr 1, 2019in Nature Genetics25.45
Amy R. Bentley15
Estimated H-index: 15
(NIH: National Institutes of Health),
Yun J. Sung7
Estimated H-index: 7
(WashU: Washington University in St. Louis)
+ 296 AuthorsXuan Deng6
Estimated H-index: 6
(BU: Boston University)
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. ...
Published on Jan 1, 2019
Paul S. de Vries14
Estimated H-index: 14
M Brown7
Estimated H-index: 7
+ 263 AuthorsNora Franceschini50
Estimated H-index: 50
Published on Jun 18, 2018in PLOS ONE2.78
Mary F. Feitosa46
Estimated H-index: 46
(WashU: Washington University in St. Louis),
Aldi T. Kraja36
Estimated H-index: 36
(WashU: Washington University in St. Louis)
+ 269 AuthorsXueling Sim45
Estimated H-index: 45
(NUS: National University of Singapore)
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucl...
Published on Dec 1, 2017in Scientific Reports4.01
Niek Verweij35
Estimated H-index: 35
(UMCG: University Medical Center Groningen),
Ruben N. Eppinga6
Estimated H-index: 6
(UMCG: University Medical Center Groningen)
+ 1 AuthorsDiana van Heemst80
Estimated H-index: 80
(UMCG: University Medical Center Groningen)
Coronary artery disease (CAD) is the major cause of morbidity and mortality in the world. Identification of novel genetic determinants may provide new opportunities for developing innovative strategies to predict, prevent and treat CAD. Therefore, we meta-analyzed independent genetic variants passing P <× 10−5 in CARDIoGRAMplusC4D with novel data made available by UK Biobank. Of the 161 genetic variants studied, 71 reached genome wide significance (p < 5 × 10−8) including 15 novel loci. These no...
Published on Jul 1, 2017in Journal of the American College of Cardiology18.64
M. Abdullah Said5
Estimated H-index: 5
Ruben N. Eppinga6
Estimated H-index: 6
+ 2 AuthorsDiana van Heemst80
Estimated H-index: 80
Telomeres are DNA repeat structures with protein complexes capping the ends of chromosomes important for chromosomal stability and cellular integrity [(1)][1]. Telomeres shorten with each cell division and under environmental conditions such as oxidative stress. Therefore, telomere length (TL) has
Published on Jun 15, 2017in Human Molecular Genetics4.54
Marten E. van den Berg9
Estimated H-index: 9
(EUR: Erasmus University Rotterdam),
Helen R. Warren19
Estimated H-index: 19
(QMUL: Queen Mary University of London)
+ 118 AuthorsHenry J. Lin4
Estimated H-index: 4
(UCLA: University of California, Los Angeles)
Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses. Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association resu...
Published on Jun 1, 2017in Nature Genetics25.45
Ingrid E. Christophersen10
Estimated H-index: 10
(Broad Institute),
Michiel Rienstra34
Estimated H-index: 34
(UG: University of Groningen)
+ 159 AuthorsChristine M. Albert64
Estimated H-index: 64
(Harvard University)
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,...
Published on Feb 1, 2017in International Journal of Cardiology3.47
M. Yldau van der Ende3
Estimated H-index: 3
(UMCG: University Medical Center Groningen),
Minke H. T. Hartman5
Estimated H-index: 5
(UMCG: University Medical Center Groningen)
+ 8 AuthorsMichiel Rienstra34
Estimated H-index: 34
(UMCG: University Medical Center Groningen)
Abstract Background The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. Methods and results Baseline cardiovascular phenotypes were defined in 9700 juvenile (8–18years) and 15...