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Haley R. Pipkins
University of Mississippi Medical Center
VirologyPneumolysinPneumococcal infectionsStreptococcus pneumoniaeVirulence
6Publications
3H-index
260Citations
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Publications 6
Newest
#1Caleb S Martin (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Jessica L. Bradshaw (UMMC: University of Mississippi Medical Center)H-Index: 4
Last. Larry S. McDaniel (UMMC: University of Mississippi Medical Center)H-Index: 30
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1 CitationsSource
#1Jessica L. Bradshaw (UMMC: University of Mississippi Medical Center)H-Index: 4
#2Armando R. Caballero (UMMC: University of Mississippi Medical Center)H-Index: 9
Last. Larry S. McDaniel (UMMC: University of Mississippi Medical Center)H-Index: 30
view all 8 authors...
ABSTRACT Pneumonia is a pulmonary disease affecting people of all ages and is consistently a leading cause of childhood mortality and adult hospitalizations. Streptococcus pneumoniae and Pseudomonas aeruginosa are major lung pathogens commonly associated with community-acquired and nosocomial pneumonia. Additionally, mixed lung infections involving these bacterial pathogens are increasing in prevalence and are frequently more severe than single infections. The cooperative interactions of these t...
3 CitationsSource
#1Haley R. Pipkins (UMMC: University of Mississippi Medical Center)H-Index: 3
#2Jessica L. Bradshaw (UMMC: University of Mississippi Medical Center)H-Index: 4
Last. Larry S. McDaniel (UMMC: University of Mississippi Medical Center)H-Index: 30
view all 4 authors...
Current Streptococcus pneumoniae vaccines selectively target capsular polysaccharide of specific serotypes, leading to an increase in nonencapsulated S. pneumoniae (NESp). Cocolonization by encapsulated pneumococci and NESp increases the opportunity for intraspecies genetic exchange. Acquisition of NESp genes by encapsulated pneumococci could alter virulence and help vaccine-targeted serotypes persist in the host. Adhesion and invasion assays were performed using immortalized human pharyngeal or...
2 CitationsSource
#1Jessica L. Bradshaw (UMMC: University of Mississippi Medical Center)H-Index: 4
#2Haley R. Pipkins (UMMC: University of Mississippi Medical Center)H-Index: 3
Last. Larry S. McDaniel (UMMC: University of Mississippi Medical Center)H-Index: 30
view all 5 authors...
ABSTRACT Nonencapsulated Streptococcus pneumoniae (NESp) is an emerging human pathogen that colonizes the nasopharynx and is associated with noninvasive diseases such as otitis media (OM), conjunctivitis, and nonbacteremic pneumonia. Since capsule expression was previously thought to be necessary for establishment of invasive pneumococcal disease (IPD), serotype-specific polysaccharide capsules are targeted by currently licensed pneumococcal vaccines. Yet, NESp expressing oligopeptide binding pr...
4 CitationsSource
#1Haley R. PipkinsH-Index: 3
Last. Larry S. McDanielH-Index: 30
view all 5 authors...
Streptococcus pneumoniae is commonly found in the human nasopharynx and is the causative agent of multiple diseases. Since invasive pneumococcal infections are associated with encapsulated pneumococci, the capsular polysaccharide is the target of licensed pneumococcal vaccines. However, there is an increasing distribution of non-vaccine serotypes, as well as nonencapsulated S. pneumoniae (NESp). Both encapsulated and nonencapsulated pneumococci possess the polyamine oligo-transport operon (potAB...
245 CitationsSource
#1Lance E. Keller (UMMC: University of Mississippi Medical Center)H-Index: 8
#2Jessica L. Bradshaw (UMMC: University of Mississippi Medical Center)H-Index: 4
Last. Larry S. McDaniel (UMMC: University of Mississippi Medical Center)H-Index: 30
view all 4 authors...
Streptococcus pneumoniae infections result in a range of human diseases and are responsible for almost one million deaths annually. Pneumococcal disease is mediated in part through surface structures and an anti-phagocytic capsule. Recent studies have shown that nonencapsulated Streptococcus pneumoniae (NESp) make up a significant portion of the pneumococcal population and are able to cause disease. NESp lack some common surface proteins expressed by encapsulated pneumococci, but express surface...
5 CitationsSource
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