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Shie Yin Ng
University of Malaya
Singlet oxygenPorphyrinPhotodynamic therapyBODIPYMedicine
3Publications
2H-index
22Citations
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Publications 4
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#1Shie Yin NgH-Index: 2
#2Anyanee Kamkaew (Suranaree University of Technology)H-Index: 2
Last. Hong Boon LeeH-Index: 10
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Abstract Active targeting compound, a non-iodinated derivative of IK-IK-I2-azaBODIPY (1a) was previously reported to preferentially bind melanoma over healthy cells. In this study, we evaluate the photodynamic therapy (PDT) efficiency on melanoma cells of 1a, together with its reversed sequence compound KI-KI-I2-azaBODIPY (1b) and a non-targeted control I2-azaBODIPY-NH2 (2). All three test compounds possess absorption wavelengths in the near-infrared (NIR) region (λmax between 678 and 687 nm) wh...
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#1Chin Siang Kue (Management and Science University)H-Index: 4
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Hong Boon Lee (UM: University of Malaya)H-Index: 7
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BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
16 CitationsSource
#1Derya TopkayaH-Index: 6
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Fabienne Dumoulin (GIT: Gebze Institute of Technology)H-Index: 17
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In this study, we focus on is the enhancement of singlet oxygen generation, which can be promoted by the introduction of heavy atoms on the photosensitizer. Metalation of tetrapyrrole core by heavy atoms such as platinum or palladium is another option but these metals tend to aggravate the aggregation tendency of the macrocycle. Halogenation proved to be much more successful on photosensitizing phthalocyanine [1] and BOPDIPY [2]. Besides, our recent systematic study on monohalogenated trihydroxy...
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#1Derya TopkayaH-Index: 6
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Fabienne Dumoulin (GIT: Gebze Institute of Technology)H-Index: 17
view all 7 authors...
University of Dokuz Eylul, Department of Chemistry, Faculty of Science, 35160, Tinaztepe, Izmir, Turkey Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia ENS Lyon, Universite de Lyon, Laboratoire de Chimie de l’ENS Lyon, UMR 5182 CNRS-ENS Lyon, 46 allee d’Italie, 69364 Lyon, France Institut de Chimie et Biochimie Moleculaires et Supramoleculaires, CO2-Glyco, UMR 5246, CNRS, Universite Claude Bernard Lyon 1, Universite de Lyon, 43 oulevard du 11 Novem...
6 CitationsSource
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