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Andrea Mazzanti
University of Turin
16Publications
12H-index
770Citations
Publications 16
Newest
#1Rossana BongianinoH-Index: 5
#2Marco DenegriH-Index: 17
Last.Silvia G. PrioriH-Index: 87
view all 15 authors...
Rationale: Mutations in the cardiac Ryanodine Receptor gene ( RYR2 ) cause dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), a leading cause of sudden death in apparently healthy individuals exposed to emotions or physical exercise. Objective: We investigated the efficacy of allele-specific silencing by RNA interference to prevent CPVT phenotypic manifestations in our dominant CPVT mice model carriers of the heterozygous mutation R4496C in RYR2 . Methods and Results: We deve...
#1Andrea MazzantiH-Index: 12
#2Kevin NgH-Index: 2
Last.Silvia G. Priori (UNIPV: University of Pavia)H-Index: 87
view all 19 authors...
Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a leading cause of sudden cardiac death, but its progression over time and predictors of arrhythmias are still being defined. Objectives This study sought to describe the clinical course of ARVC and occurrence of life-threatening arrhythmic events (LAE) and cardiovascular mortality; identify risk factors associated with increased LAE risk; and define the response to therapy. Methods We determined the clinical course of...
#1Jacopo F. ImbertiH-Index: 1
Last.Silvia G. Priori (UNIPV: University of Pavia)H-Index: 87
view all 4 authors...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable cardiac disorder associated with exercise- and stress-induced sudden death in young individuals. Although important steps forward have been made in the comprehension and treatment of this disease, several aspects remain unclear. Firstly, from an epidemiological standpoint the actual prevalence of CPVT is still unknown and possibly underestimated. In addition, the diagnostic process remains very challenging and can be ...
#1Andrea MazzantiH-Index: 12
#2Riccardo MaragnaH-Index: 5
Last.Silvia G. Priori (UNIPV: University of Pavia)H-Index: 87
view all 12 authors...
Abstract Background Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5. Mexiletine is used to block late sodium current and to shorten QT interval in LQT3 patients. Objectives The aim of this study was to determine whether mexiletine prevents arrhythmic events (arrhythmic syncope, aborted cardiac arrest, or sudden cardiac death) in LQT3 patients. Methods The endpoint of this retrospe...
#1Jakub Sroubek (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Vincent ProbstH-Index: 45
Last.Steven A. Lubitz (Harvard University)H-Index: 45
view all 24 authors...
Background —The role of programmed ventricular stimulation (PVS) in identifying Brugada syndrome patients at highest risk for sudden death is uncertain. Methods and Results —We performed a systematic review and pooled analysis of prospective observational studies of Brugada syndrome patients without a history of sudden cardiac arrest who underwent PVS. We estimated incidence rates and relative hazards of cardiac arrest or ICD shock. We analyzed individual-level data from 8 studies, comprising 13...
#1Silvia G. PrioriH-Index: 77
#2Carina Blomström-Lundqvist (Uppsala University)H-Index: 45
Last.Faiez ZannadH-Index: 93
view all 47 authors...
Los miembros del Comite de la ESC para la Elaboracion de GPC y los revisores del documento representantes de las sociedades nacionales de cardiologia aparecen listados en el apendice. Se puede consultar las declaraciones de conflicto de intereses de los expertos participantes en el desarrollo de esta guia en la pagina web de la ESC: www.escardio.org/guidelines
#2Michael Arad (TAU: Tel Aviv University)H-Index: 28
Last.Lorenzo MonserratH-Index: 28
view all 18 authors...
Objectives The prognostic value of genetic studies in cardiomyopathies is still controversial. Our objective was to evaluate the outcome of patients with cardiomyopathy with mutations in the converter domain of β myosin heavy chain (MYH7). Methods Clinical characteristics and survival of 117 affected members with mutations in the converter domain of MYH7 were compared with 409 patients described in the literature with mutations in the same region. Results Twenty-five mutations were evaluated (9 ...
#1Daniel T. Harrell (Nagasaki University)H-Index: 4
#2Takashi Ashihara (Shiga University of Medical Science)H-Index: 20
Last.Naomasa Makita (Nagasaki University)H-Index: 37
view all 14 authors...
Abstract Background Short QT syndrome (SQTS) is a rare inheritable arrhythmia, associated with atrial and ventricular fibrillations, caused by mutations in six cardiac ion channel genes with high penetrance. However, genotype-specific clinical differences between SQTS patients remain to be elucidated. Methods and results We screened five unrelated Japanese SQTS families, and identified three mutations in KCNH2 and KCNQ1 . A novel mutation KCNH2 -I560T, when expressed in COS-7 cells, showed a 2.5...
#1Carla Giustetto (UNITO: University of Turin)H-Index: 25
#2Chiara Scrocco (UNITO: University of Turin)H-Index: 7
Last.Fiorenzo Gaita (UNITO: University of Turin)H-Index: 60
view all 15 authors...
Aims Short QT syndrome (SQTS) is a rare arrhythmogenic inherited heart disease. Diagnosis can be challenging in subjects with slightly shortened QT interval at electrocardiogram. In this study we compared the QT interval behaviour during exercise in a cohort of SQTS patients with a control group, to evaluate the usefulness of exercise test in the diagnosis of SQTS. Methods and results Twenty-one SQTS patients and 20 matched control subjects underwent an exercise test. QT interval was measured at...
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