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Jamie T. Carrington
University of Dundee
2Publications
2H-index
57Citations
Publications 2
Newest
#1Nicola J. Gardner (Dund.: University of Dundee)H-Index: 1
#2Peter J. Gillespie (Dund.: University of Dundee)H-Index: 15
Last.J. Julian Blow (Dund.: University of Dundee)H-Index: 60
view all 9 authors...
Summary In late mitosis and G 1 , origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2–7. A "licensing checkpoint" delays cells in G 1 until sufficient origins have been licensed, but this checkpoint is lost in cancer cells. Inhibition of licensing can therefore kill cancer cells while only delaying normal cells in G 1 . In a high-throughput cell-based screen for licensing inhibitors we...
4 CitationsSource
#1Alberto Moreno (Dund.: University of Dundee)H-Index: 15
#2Jamie T. Carrington (Dund.: University of Dundee)H-Index: 2
Last.J. Julian Blow (Dund.: University of Dundee)H-Index: 60
view all 9 authors...
To prevent rereplication of genomic segments, the eukaryotic cell cycle is divided into two nonoverlapping phases. During late mitosis and G1 replication origins are “licensed” by loading MCM2-7 double hexamers and during S phase licensed replication origins activate to initiate bidirectional replication forks. Replication forks can stall irreversibly, and if two converging forks stall with no intervening licensed origin—a “double fork stall” (DFS)—replication cannot be completed by conventional...
53 CitationsSource
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