Alison L. Van Dyke
National Institutes of Health
Publications 12
#1Sarah S. JacksonH-Index: 6
#2Alison L. Van DykeH-Index: 3
Last.Jill KoshiolH-Index: 25
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Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measu...
1 CitationsSource
#2Alison L. Van DykeH-Index: 3
Last.Lynne PenberthyH-Index: 30
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Although fresh frozen tissue is the optimal source of nucleic acids for sequencing, obtaining such tissue on a population scale is cost and time prohibitive; however, DNA and RNA extraction from formalin-fixed, paraffin-embedded (FFPE) tissue has been problematic, yielding low quantity and quality DNA and RNA. Through a pilot program, the National Cancer Institute is developing a Surveillance, Epidemiology and End Results (SEER)-linked Virtual Tissue Repository (VTR) for obtaining deidentified F...
#1Yao Yuan (NIH: National Institutes of Health)
#2Alison L. Van Dyke (NIH: National Institutes of Health)H-Index: 3
Last.Valentina I. Petkov (NIH: National Institutes of Health)H-Index: 8
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e12046Background: OncotypeDX DCIS is a 12-gene assay designed to predict the 10-year risk of local recurrence and to guide treatment decisions, specifically the benefit of radiation therapy in brea...
#1Alison L. Van Dyke (NIH: National Institutes of Health)H-Index: 3
#2Meredith S. Shiels (NIH: National Institutes of Health)H-Index: 32
Last.Jill Koshiol (NIH: National Institutes of Health)H-Index: 25
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1 CitationsSource
Obesity and diabetes are associated with an increased liver cancer risk. However, most studies have examined all primary liver cancers or hepatocellular carcinoma, with few studies evaluating intrahepatic cholangiocarcinoma (ICC), the second most common type of liver cancer. Thus, we examined the association between obesity and diabetes and ICC risk in a pooled analysis and conducted a systematic review/meta-analysis of the literature. For the pooled analysis, we utilized the Liver Cancer Poolin...
6 CitationsSource
#1Alison L. Van Dyke (NIH: National Institutes of Health)H-Index: 3
#2Margaret S Langhamer (Emory University)H-Index: 1
Last.Jill Koshiol (NIH: National Institutes of Health)H-Index: 25
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Background:Although some familial cancer syndromes include biliary tract cancers (BTCs) (cancers of the gallbladder, intrahepatic and extrahepatic bile ducts, and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings. The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP). Methods: We used Cox proportional ha...
2 CitationsSource
#1Jessica L. PetrickH-Index: 14
#2Baiyu YangH-Index: 8
Last.Katherine A. McGlynnH-Index: 35
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Abstract Intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinomas are rare tumors that arise from the epithelial cells of the bile ducts, and the etiology of both cancer types is poorly understood. Thus, we utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare resource to examine risk factors and novel preexisting medical conditions that may be associated with these cancer types. Between 2000 and 2011, 2,092 ICC and 2,981 ECC cases and 323,615 controls were identified usi...
21 CitationsSource
#1Jill KoshiolH-Index: 25
#2Ying GaoH-Index: 96
Last.John Davis Groopman (Johns Hopkins University)H-Index: 69
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Background & Aims Aflatoxin, which causes hepatocellular carcinoma, may also cause gallbladder cancer. We investigated whether patients with gallbladder cancer have higher exposure to aflatoxin than patients with gallstones. Methods We measured aflatoxin B 1 (AFB 1 )–lysine adducts in plasma samples from the Shanghai Biliary Tract Cancer case-control study, conducted from 1997 through 2001. We calculated age- and sex-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and the populatio...
10 CitationsSource
#1Alison L. Van DykeH-Index: 3
Last.Mahboobeh SafaeianH-Index: 28
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