Evangelos Papanastasiou
King's College London
PsychiatryPsychosisMetabolic syndromeMedicineSchizophrenia
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Publications 9
#1Evangelos Papanastasiou ('KCL': King's College London)H-Index: 6
#2Elias Mouchlianitis ('KCL': King's College London)H-Index: 5
Last. Sylvane Desrivières ('KCL': King's College London)H-Index: 25
view all 30 authors...
Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal region...
#1Evangelos Papanastasiou ('KCL': King's College London)H-Index: 6
#2Elias Mouchlianitis ('KCL': King's College London)H-Index: 5
Last. Sukhwinder S. Shergill ('KCL': King's College London)H-Index: 41
view all 30 authors...
Importance Psychoticlike experiences (PLEs) are subclinical manifestations of psychotic symptoms and may reflect an increased vulnerability to psychotic disorders. Contemporary models of psychosis propose that dysfunctional reward processing is involved in the cause of these clinical illnesses. Objective To examine the neuroimaging profile of healthy adolescents at 14 and 19 years old points with PLEs, using a reward task. Design, Setting, and Participants A community-based cohort study, using b...
5 CitationsSource
#1Fiona Gaughran (South London and Maudsley NHS Foundation Trust)H-Index: 29
#2John Lally (Beaumont Hospital)H-Index: 16
Last. Robin M. Murrayand (South London and Maudsley NHS Foundation Trust)H-Index: 149
view all 14 authors...
Abstract There has been much recent excitement about the possibility that some cases of psychosis may be wholly due to brain-reactive antibodies, with antibodies to N-methyl-D-aspartate receptor (NMDAR) and the voltage-gated potassium channel (VGKC)-complex reported in a few patients with first-episode psychosis (FEP). Participants were recruited from psychiatric services in South London, UK, from 2009 to 2011 as part of the Genetics and Psychosis study. We conducted a case-control study to exam...
7 CitationsSource
#1Poonam Gardner-Sood ('KCL': King's College London)H-Index: 12
#2John Lally ('KCL': King's College London)H-Index: 16
Last. Fiona Gaughran (South London and Maudsley NHS Foundation Trust)H-Index: 29
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BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.METHOD: Baseline data were collected as part of a large randomized controlled tria...
55 CitationsSource
#1Paolo Fusar-Poli ('KCL': King's College London)H-Index: 66
#2Evangelos Papanastasiou ('KCL': King's College London)H-Index: 6
Last. Philip McGuire ('KCL': King's College London)H-Index: 110
view all 7 authors...
Objectives: Existing treatments for schizophrenia can improve positive symptoms, but it is unclear if they have any impact on negative symptoms. This meta-analysis was conducted to assess the efficacy of available treatments for negative symptoms in schizophrenia.
176 CitationsSource
Metabolic syndrome (MetS), a constellation of central obesity, hypertension, dyslipidaemia and glucose intolerance, is highly prevalent in individuals with schizophrenia and conveys significant cardiovascular risk and mortality. Associated risk factors are female sex, some ethnic groups, advanced age, long duration of illness, smoking and exposure to antipsychotic agents. The prevalence of MetS varies across countries and psychiatric populations, and its development can be very rapid. Regular mo...
53 CitationsSource
Currently available antipsychotic drugs target dopaminergic neurotransmission. Many patients do not respond fully to these treatments, and there has been considerable effort to investigate alternative targets. Here we summarise the rationale and recent evidence supporting efforts to develop glutamatergic antipsychotic drugs.
19 CitationsSource
The metabolic syndrome (MetS) is an increasingly prevalent condition in people with schizophrenia. It remains highly prevalent in the general population in developed countries, but recently health promotion campaigns and greater awareness of the high associated mortality rates have resulted in improvements in the rates of cardiovascular risk factors. This is not the case for people with schizophrenia who continue to have more than twice the rates of MetS and significantly higher mortality rates ...
29 CitationsSource