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Masamori Iwase
University of Tokyo
2Publications
1H-index
7Citations
Publications 2
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#1Masamori Iwase (UTokyo: University of Tokyo)H-Index: 1
#2Kyoko Watanabe (Tokyo University of Agriculture)
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
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ABSTRACTSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthetic pathways. The present...
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#1Ayasa OchiaiH-Index: 2
#2Shingo MiyataH-Index: 17
Last.Ryuichiro SatoH-Index: 37
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A high level of plasma low-density lipoprotein (LDL) cholesterol is considered a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) is essential for clearing plasma LDL cholesterol, activation of LDLR is a promising therapeutic target for patients with atherosclerotic disease. Here we demonstrated how the flavonoid kaempferol stimulated the gene expression and activity of LDLR in HepG2 cells. The kaempferol-mediated stimulation of LDLR gene expression was completely inhibit...
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