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Christina Priest
University of California, Los Angeles
3Publications
1H-index
11Citations
Publications 5
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#1Christina Priest (UCLA: University of California, Los Angeles)H-Index: 1
#2Peter Tontonoz (UCLA: University of California, Los Angeles)H-Index: 80
Maintenance of systemic homeostasis and the response to nutritional and environmental challenges require the coordination of multiple organs and tissues. To respond to various metabolic demands, higher organisms have developed a system of inter-organ communication through which one tissue can affect metabolic pathways in a distant tissue. Dysregulation of these lines of communication contributes to human pathologies, including obesity, diabetes, liver disease and atherosclerosis. In recent years...
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#1Stephen Lee (UCLA: University of California, Los Angeles)H-Index: 27
#2Christina Priest (UCLA: University of California, Los Angeles)H-Index: 1
Last.Cynthia Hong (UCLA: University of California, Los Angeles)H-Index: 31
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Liver X receptors limit cellular lipid uptake by stimulating the transcription of inducible degrader of the low-density lipoprotein receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The function of IDOL in systemic metabolism is incompletely understood. Here we show that loss of IDOL in mice protects against the development of diet-induced obesity and metabolic dysfunction by altering food intake and thermogenesis. Unexpectedly, analysis of tissue-specif...
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#1Li Zhang (UCLA: University of California, Los Angeles)H-Index: 33
#2Prashant Rajbhandari (UCLA: University of California, Los Angeles)H-Index: 9
Last.Peter Tontonoz (UCLA: University of California, Los Angeles)H-Index: 80
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10 CitationsSource
#1Lanjun Zhang (UCLA: University of California, Los Angeles)H-Index: 69
#2Li Zhang (UCLA: University of California, Los Angeles)H-Index: 33
Last.Peter Tontonoz (UCLA: University of California, Los Angeles)H-Index: 80
view all 10 authors...
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#1Christina Priest (UCLA: University of California, Los Angeles)H-Index: 1
#2Peter Tontonoz (UCLA: University of California, Los Angeles)H-Index: 80
The development of atherosclerosis is countered by the reverse transport of cholesterol from peripheral tissues to the liver for excretion. In this issue of Cell Metabolism, Stein et al. (2014) establish LRH-1 as an important regulator of reverse cholesterol transport and identify SUMOylation as a primary mode of LRH-1 regulation.
1 CitationsSource
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