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Jean S. McGee
Boston University
16Publications
3H-index
81Citations
Publications 16
Newest
#1Emily Mann (BU: Boston University)
#2Rohit Maruthi (BU: Boston University)H-Index: 1
Last.Jean S. McGee (BU: Boston University)H-Index: 3
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#1Edward Kim (BU: Boston University)H-Index: 2
#2Beth E. Zucconi (Harvard University)H-Index: 9
Last.Rhoda M. Alani (BU: Boston University)H-Index: 28
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Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms governing human diseases, including cancer. Despite significant effort and recent advances, the mechanism by which the HAT and transcriptional coactivator p300 mediates tumorigenesis remains unclear. Here, we use a genetic and chemical approach to identify the microphthalmia-associated transcription factor (MITF) as a critical downstream targe...
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#2Sang Ju LeeH-Index: 14
Last.Hye Jin ChungH-Index: 12
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#1Joshua S. Mervis (BU: Boston University)H-Index: 2
#2Jean S. McGee (BU: Boston University)H-Index: 3
The epigenetic regulation of gene expression is accomplished primarily through DNA methylation, histone modification, and gene silencing via the action of microRNAs. While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. Moreover, evidence has emerged that epigenetic dysregulation plays a ca...
1 CitationsSource
#1Jean S. McGee (BU: Boston University)H-Index: 3
#2Jonathan K. WilkinH-Index: 1
In 1951, the Durham-Humphrey Amendment to the US Federal Food, Drug, and Cosmetic Act of 1938 was enacted to label medications into 2 specific categories: prescription vs over the counter (OTC). This amendment required that any habit-forming or potentially harmful medications be dispensed under the direct guidance of a health care professional. “Rx to OTC switch” is defined as the transfer of prescription drugs to OTC status; it is a data-driven process, rigorously regulated by the US Food and D...
1 CitationsSource
#1Anna Eisenstein (BU: Boston University)H-Index: 6
#2Estela Chen Gonzalez (BU: Boston University)H-Index: 1
Last.Rhoda M. Alani (BU: Boston University)H-Index: 28
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Earlier identification of aggressive melanoma remains a goal in the field of melanoma research. With new targeted and immune therapies that have revolutionized the care of patients with melanoma, the ability to predict progression and monitor or predict response to therapy has become the new focus of research into biomarkers in melanoma. In this review, promising biomarkers are highlighted. These biomarkers have been used to diagnose melanoma as well as predict progression to advanced disease an...
1 CitationsSource
#1Jean S. McGee (BU: Boston University)H-Index: 3
#2Won Soon Chung (Yonsei University)H-Index: 7
Last.Hye Jin Chung (BU: Boston University)H-Index: 12
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#1Jean S. McGeeH-Index: 3
#2Won Soon ChungH-Index: 7
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#2Jonathan D. HoH-Index: 1
Last.Jag BhawanH-Index: 34
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Autoimmunity-associated neutrophilic dermatoses are a recently recognized manifestation of connective tissue diseases, in particular, lupus erythematosus. These entities are clinically and sometimes histopathologically distinct from classic neutrophilic dermatoses. We describe a case of an autoimmunity-related neutrophilic dermatosis in a patient with rheumatoid arthritis. In addition to this uncommon association, there was an absence of mature neutrophils and a population of immature histiocyto...
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