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Ikuro Maruyama
Kagoshima University
136Publications
38H-index
5,361Citations
Publications 136
Newest
#1Shusaku Yamada (TUAT: Tokyo University of Agriculture and Technology)H-Index: 1
#2Daiki Hirao (TUAT: Tokyo University of Agriculture and Technology)H-Index: 2
Last.Ryuji Fukushima (TUAT: Tokyo University of Agriculture and Technology)H-Index: 7
view all 10 authors...
Source
#1Takashi Ito (Kadai: Kagoshima University)H-Index: 23
#2M Nakahara (Kadai: Kagoshima University)H-Index: 3
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 10 authors...
Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.
2 CitationsSource
#1Kiyoshi KikuchiH-Index: 27
#2Kentaro Setoyama (Kadai: Kagoshima University)H-Index: 8
Last.Salunya Tancharoen (MU: Mahidol University)H-Index: 18
view all 20 authors...
Uric acid (UA) therapy may prevent early ischemic worsening after acute stroke in thrombolysis patients. The aim of this study was to examine the influence of UA on the thrombolytic efficacy of alteplase in human blood samples by measuring thrombolysis under flow conditions using a newly developed microchip-based flow-chamber assay. Human blood samples from healthy volunteers were exposed to UA, alteplase, or a combination of UA and alteplase. Whole blood and platelet-rich plasma were perfused o...
1 CitationsSource
#1Shusaku Yamada (TUAT: Tokyo University of Agriculture and Technology)H-Index: 1
#2Daiki Hirao (TUAT: Tokyo University of Agriculture and Technology)H-Index: 2
Last.Ryuji Fukushima (TUAT: Tokyo University of Agriculture and Technology)H-Index: 7
view all 10 authors...
Abstract Introduction Changes in blood characteristics in the atrium and peripheral vessels in patients with non-valvular atrial fibrillation (NVAF) are unclear. We investigated chronological changes in blood characteristics in the atrium and peripheral vessels in a dog model of NVAF by using a total thrombus-formation analysis system (T-TAS). Materials and methods In NVAF model dogs (n = 8, 390 bpm rapid atrial pacing), atrial and peripheral blood samples were collected. Using this blood, T-TAS...
Source
#1Noboru Taniguchi (University of Miyazaki)H-Index: 20
#2Yasuhiko Kawakami (UMN: University of Minnesota)H-Index: 36
Last.Martin Lotz (Scripps Research Institute)H-Index: 85
view all 4 authors...
The high-mobility group box (HMGB) family includes four members: HMGB1, 2, 3 and 4. HMGB proteins have two functions. In the nucleus, HMGB proteins bind to DNA in a DNA structure-dependent but nucleotide sequence-independent manner to function in chromatin remodeling. Extracellularly, HMGB proteins function as alarmins, which are endogenous molecules released upon tissue damage to activate the immune system. HMGB1 acts as a late mediator of inflammation and contributes to prolonged and sustained...
13 CitationsSource
#1Kohtaro GotoH-Index: 12
#2Hiroko IdeoH-Index: 11
Last.Akio MatsudaH-Index: 2
view all 10 authors...
Abstract Synthesis of several 1,5-Anhydro- d -fructose (1,5-AF) derivatives to evaluate inhibitory activities of the inflammasome was carried out. Recently, 1,5-AF reported to suppress the inflammasome, although with only low activity. We focused on the hydration of 2-keto form of 1,5-AF and speculated that this hydration was the cause of low activity. Therefore, we synthesized some 1,5-AF derivatives that would not be able to form the dimer conformation and can be expected to have high activity...
2 CitationsSource
#1Kenji Tanaka (NARA: National Archives and Records Administration)H-Index: 4
#2Tancharoen Salunya (MU: Mahidol University)H-Index: 1
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 7 authors...
1 CitationsSource
The combination of alteplase, a recombinant tissue plasminogen activator, and edaravone, an antioxidant, reportedly enhances recanalization after acute ischemic stroke. We examined the influence of edaravone on the thrombolytic efficacy of alteplase by measuring thrombolysis using a newly developed microchip-based flow-chamber assay. Rat models of embolic cerebral ischemia were treated with either alteplase or alteplase-edaravone combination therapy. The combination therapy significantly reduced...
4 CitationsSource
High mobility group box 1 (HMGB1) is tightly connected to the process of tissue organization upon tissue injury. Here we show that HMGB1 controls epithelium and connective tissue regeneration both in vivo and in vitro during palatal wound healing. Heterozygous HMGB1 (Hmgb1+/−) mice and Wild-type (WT) mice were subjected to palatal injury. Maxillary tissues were stained with Mallory Azan or immunostained with anti-HMGB1, anti-proliferating cell nuclear antigen (PCNA), anti-nuclear factor-κB (NF-κ...
4 CitationsSource
#1Kazuya HosokawaH-Index: 11
Last.Tetsumei Urano (Hamamatsu University)H-Index: 37
view all 9 authors...
Abstract Introduction Despite the proven benefits of thrombolytic therapy with tissue plasminogen activator (t-PA) for peripheral thromboembolism, perfusion failure frequently occurs, particularly in arterial circulation. We evaluated how the modification of fibrinolytic activity affects thrombus formation under flow and static conditions. Materials and methods t-PA-treated human whole-blood samples (n = 6) were perfused over a microchip coated with collagen and tissue thromboplastin at differen...
6 CitationsSource
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