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Shubhajit Paul
University of Minnesota
Ultimate tensile strengthChemistryCompactionTabletingChromatography
24Publications
9H-index
227Citations
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Publications 28
Newest
#1Hongbo Chen (UMN: University of Minnesota)H-Index: 1
Last. Changquan Calvin SunH-Index: 30
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Punch-sticking during tablet compression is a common problem for many active pharmaceutical ingredients (APIs), which renders tablet formulation development challenging. Herein, we demonstrate that...
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#1Shahab Kashani Rahimi (University of Texas at Austin)H-Index: 5
#1Shahab Kashani Rahimi (University of Texas at Austin)
Last. Feng Zhang (University of Texas at Austin)H-Index: 13
view all 4 authors...
Abstract This study aimed at systematically investigating the role of distributive comb mixing element (GLC) and neutral dispersive mixing kneading block element (K90) on the structure and physical properties of granules containing high-dose of poorly water-soluble drug. Albendazole was used as the model drug at 50 wt% drug loading. Lactose monohydrate and microcrystalline cellulose were used as diluent, and 3 w/v% hydroxypropyl cellulose aqueous solution was used as binder liquid. It was found ...
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#1Shubhajit PaulH-Index: 9
#2Lisa J. TaylorH-Index: 6
Last. Changquan Calvin SunH-Index: 30
view all 8 authors...
Punch sticking during tablet manufacturing is a common problem facing the pharmaceutical industry. Using several model compounds, effects of crystal size and shape of active pharmaceutical ingredients (API) on punch sticking propensity were systematically investigated in this work to provide molecular insights into the punch sticking phenomenon. In contrast to the common belief that smaller API particles aggravates punch sticking, results show that particle size reduction can either reduce or en...
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#1Cosima Hirschberg (UCPH: University of Copenhagen)H-Index: 3
#2Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
Last. Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
view all 4 authors...
Abstract Density is an important material property for evaluating, or developing a tablet formulation. In-die compressibility data can be obtained using a small amount of powder with the help of a compaction simulator. However, compacts undergo volume expansion upon ejection from die. Therefore, accurate out-of-die compressibility profiles cannot be directly obtained from the in-die data. By splitting the tablet elastic recovery into three components (in-die axial, out-of-die axial, radial), we ...
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#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Pirjo Tajarobi (AstraZeneca)H-Index: 7
Last. Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
view all 4 authors...
Abstract Mannitol and lactose are commonly used fillers in pharmaceutical tablets, available in several commercial grades that are produced using different manufacturing processes. These grades significantly differ in particulate and powder properties that impact tablet manufacturability. Choice of sub-optimum type or grade of excipient in tablet formulation can lead to manufacturing problems and difficulties, which are magnified during a continuous manufacturing process. Previous characterizati...
1 CitationsSource
#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Chenguang Wang (UMN: University of Minnesota)H-Index: 6
Last. Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
view all 4 authors...
Powder adhesion or sticking onto punches is one of the outstanding issues in pharmaceutical tablet manufacturing. We show in this work that, at comparable particle sizes, the acesulfame potassium exhibited pronouncedly reduced propensity to punch sticking than acesulfame. Detailed analyses revealed strong correlation between sticking propensity and crystal mechanical properties and surface chemistry. The free acid was highly plastic with high cohesive strength, while the salt form was brittle. D...
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#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Paul Wan Sia Heng (NUS: National University of Singapore)H-Index: 37
Last. Lai Wah Chan (NUS: National University of Singapore)H-Index: 30
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#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Shao-Yu Chang (UMN: University of Minnesota)H-Index: 5
Last. Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
view all 8 authors...
Abstract Appropriate selection of excipient grade during tablet formulation development depends on thorough knowledge in their compaction and flow properties. Each chemically unique pharmaceutical excipient is usually available in several commercial grades that are widely different in powder properties, which influence their performance for a specific formulation application. In this work, 11 grades of mannitol were systematically characterized, in terms of their particulate, flow and tableting ...
7 CitationsSource
#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
Abstract As an essential formulation component for large-scale tablet manufacturing, the lubricant preserves tooling by reducing die-wall friction. Unfortunately, lubrication also often results in adverse effects on tablet characteristics, such as prolonged disintegration, slowed dissolution, and reduced mechanical strength. Therefore, the choice of lubricant and its optimal concentration in a tablet formulation is a critical decision in tablet formulation development to attain low die-wall fric...
5 CitationsSource
#1Shubhajit Paul (UMN: University of Minnesota)H-Index: 9
#2Changquan Calvin Sun (UMN: University of Minnesota)H-Index: 30
Purpose To investigate how excipient matrix affects punch sticking propensity of active pharmaceutical ingredients (API), with the focus on the effect of bonding interactions between API-API (F2) and API-excipient (F3).
4 CitationsSource
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