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Xinjing Wang
Shanghai Jiao Tong University
17Publications
6H-index
86Citations
Publications 17
Newest
#1Xin Chen (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xiaoduan Li (SJTU: Shanghai Jiao Tong University)
Last.Xipeng Wang (SJTU: Shanghai Jiao Tong University)H-Index: 4
view all 6 authors...
Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) to the cytoplasm and consequently activates ras homolog (Rho) GTPases RhoA/Cdc42 activation to modulate the proliferation and migration abilities of EOC cells. We collect 94 ovarian cancer (OC) patients’ tissue samples to constitute tissue microarray (TMA) and analyze the MUC16 and p120ctn ...
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Yuan Fang (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 12 authors...
Long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that melittin treatment suppressed PDAC tumor growth. However, it is unclear whether lncRNAs have any role in the melittin-induced suppression of PDAC. In this study, we used microarray data to identify 844 lncRNAs that were significantly differentially expressed in response to melittin treatment. Of these lncRNAs, we focused on the lncRNA NONHSAT105177, which ha...
#1Xin Chen (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Jieru Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last.Xipeng Wang (SJTU: Shanghai Jiao Tong University)H-Index: 4
view all 6 authors...
Abstract Recently, cancer has been considered to be a complex system that includes the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most common immune-related stromal cells in the TME, and communication between cancer cells and TAMs is crucial for the progression of epithelial ovarian cancer (EOC). In this study, we revealed that exosomes derived from EOC cells remodel macrophages to a tumor-promoted phenotype, namely TAMs. In addition, hypoxic microenvironments have...
#1Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last.Chenghong Peng (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 11 authors...
Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion and metastasis. Recent evidence indicates that the long noncoding RNA NORAD may be a potential oncogenic gene and that this lncRNA is significantly upregulated during hypoxia. However, the overall biological role and clinical significance of NORAD remains la...
#1Hongzhe LiH-Index: 3
#2Xinjing WangH-Index: 6
Last.Baiyong ShenH-Index: 18
view all 9 authors...
// Hongzhe Li 1, 2, 3, * , Xinjing Wang 1, 2, 3, * , Yuan Fang 1, 2, 3 , Zhen Huo 1, 2 , Xiongxiong Lu 1, 3 , Xi Zhan 1, 3 , Xiaxin Deng 1, 3 , Chenghong Peng 1, 3 and Baiyong Shen 1, 2, 3 1 Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 2 Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 3 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, S...
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Jing Xie (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Hao Chen (SJTU: Shanghai Jiao Tong University)H-Index: 15
view all 14 authors...
Abstract Melittin is a Chinese traditional medicine for treating chronic inflammation, immunological diseases and cancers, however, the efficacy of melittin and its mechanism for treating pancreatic ductal adenocarcinoma (PDAC) are still unknown. Here we investigated the anti-cancer activity of melittin and its regulated mechanism(s) in the PDAC models. Melittin was found to suppress tumor growth by promoting cell apoptosis and cell-cycle arrest. Interestingly, the microarray analyses demonstrat...
#1Tian Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last.Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 8 authors...
Background This article was aimed to show the safety, flexibility and other advantages of transperitoneal robot-assisted resection of benign primary retroperitoneal tumors. Methods Ten patients underwent robotic surgeries, and 31 underwent laparotomy surgeries from 2012 to 2014. The perioperative data, including tumor size, operation time, and other parameters were analyzed. Results The tumor sizes of the two groups were not different (robotic group vs laparotomy group: 5.47 vs 5.32 cm, respecti...
#1Jing Xie (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xiongxiong Lu (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last.Xiaomei Tang (SJTU: Shanghai Jiao Tong University)H-Index: 3
view all 19 authors...
Background Targeted therapies including monoclonal antibodies and small molecule inhibitors have dramatically changed the treatment of cancer over past 10 years. Their therapeutic advantages are more tumor specific and with less side effects. For precisely tailoring available targeted therapies to each individual or a subset of cancer patients, next-generation sequencing (NGS) has been utilized as a promising diagnosis tool with its advantages of accuracy, sensitivity, and high throughput. Metho...
#1Xinjing WangH-Index: 6
#2Xiongxiong LuH-Index: 7
Last.Yuan FangH-Index: 6
view all 12 authors...
// Xinjing Wang 1,2,3,* , Xiongxiong Lu 1,2,3,* , Tian Zhang 1,2,3,* , Chenlei Wen 1,2,3 , Minmin Shi 3 , Xiaomei Tang 1,2,3 , Hao Chen 1,2,3 , Chenghong Peng 1,2,3 , Hongwei Li 1 , Yuan Fang 1,2,3 , Xiaxing Deng 1,2,3 and Baiyong Shen 1,2,3 1 Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 2 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 3 Shanghai Instit...
#1Tian Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last.Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 9 authors...
BACKGROUND Postoperative pancreatic fistulas (POPFs) due to anastomotic leaks are always closely related to significant morbidity and mortality following pancreaticoduodenectomy (PD). A series of modified anastomotic methods have been proposed. The object of our study was to provide a novel anastomotic method for operations involving the Child technique, termed the "whole-layer tightly appressed anastomosis technique". MATERIAL AND METHODS An improved pancreatic whole-layer suture technique was ...
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