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Xinjing Wang
Shanghai Jiao Tong University
SurgeryPancreatic cancerPancreatic fistulaCancer researchMedicine
19Publications
7H-index
188Citations
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Publications 15
Newest
#1Xiaoduan Li (Tongji University)H-Index: 3
#2Meiling Tang (Tongji University)H-Index: 2
Last. Xipeng Wang (Tongji University)H-Index: 5
view all 6 authors...
Epithelial ovarian cancer (EOC) is one of the most malignant cancers in the gynecologic system. Many patients are diagnosed at an advanced stage with disseminated intra-peritoneal metastases. EOC spreads via both direct extension and trans-coelomic spread. However, the interplay between human peritoneal mesothelial cells (HPMCs) and EOC cells is still ambiguous. We hypothesize that integrins (ITG) in HPMCs may play important roles in EOC metastasis. The expression of different integrin subtypes ...
2 CitationsSource
#1Chenlei Wen (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Ke Huang (Fudan University)H-Index: 3
Last. Lu ZhouH-Index: 9
view all 32 authors...
Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest malignancies worldwide. By uncovering the elevated PGAM1 expressions were statistically related to worse prognosis of PDAC in a cohort of 50 patients, we developed a series of allosteric PGAM1 inhibitors by stru...
3 CitationsSource
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 12 authors...
Long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that melittin treatment suppressed PDAC tumor growth. However, it is unclear whether lncRNAs have any role in the melittin-induced suppression of PDAC. In this study, we used microarray data to identify 844 lncRNAs that were significantly differentially expressed in response to melittin treatment. Of these lncRNAs, we focused on the lncRNA NONHSAT105177, which ha...
7 CitationsSource
#1Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 11 authors...
Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion and metastasis. Recent evidence indicates that the long noncoding RNA NORAD may be a potential oncogenic gene and that this lncRNA is significantly upregulated during hypoxia. However, the overall biological role and clinical significance of NORAD remains la...
37 CitationsSource
#1Hongzhe LiH-Index: 5
#2Xinjing WangH-Index: 7
Last. Baiyong ShenH-Index: 19
view all 9 authors...
// Hongzhe Li 1, 2, 3, * , Xinjing Wang 1, 2, 3, * , Yuan Fang 1, 2, 3 , Zhen Huo 1, 2 , Xiongxiong Lu 1, 3 , Xi Zhan 1, 3 , Xiaxin Deng 1, 3 , Chenghong Peng 1, 3 and Baiyong Shen 1, 2, 3 1 Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 2 Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 3 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, S...
14 CitationsSource
#1Tian Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 8 authors...
Background This article was aimed to show the safety, flexibility and other advantages of transperitoneal robot-assisted resection of benign primary retroperitoneal tumors. Methods Ten patients underwent robotic surgeries, and 31 underwent laparotomy surgeries from 2012 to 2014. The perioperative data, including tumor size, operation time, and other parameters were analyzed. Results The tumor sizes of the two groups were not different (robotic group vs laparotomy group: 5.47 vs 5.32 cm, respecti...
1 CitationsSource
#1Xinjing WangH-Index: 7
#2Xiongxiong LuH-Index: 10
Last. Baiyong ShenH-Index: 19
view all 12 authors...
// Xinjing Wang 1,2,3,* , Xiongxiong Lu 1,2,3,* , Tian Zhang 1,2,3,* , Chenlei Wen 1,2,3 , Minmin Shi 3 , Xiaomei Tang 1,2,3 , Hao Chen 1,2,3 , Chenghong Peng 1,2,3 , Hongwei Li 1 , Yuan Fang 1,2,3 , Xiaxing Deng 1,2,3 and Baiyong Shen 1,2,3 1 Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 2 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 3 Shanghai Instit...
12 CitationsSource
#1Tian Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 9 authors...
BACKGROUND Postoperative pancreatic fistulas (POPFs) due to anastomotic leaks are always closely related to significant morbidity and mortality following pancreaticoduodenectomy (PD). A series of modified anastomotic methods have been proposed. The object of our study was to provide a novel anastomotic method for operations involving the Child technique, termed the "whole-layer tightly appressed anastomosis technique". MATERIAL AND METHODS An improved pancreatic whole-layer suture technique was ...
2 CitationsSource
#1Xiongxiong LuH-Index: 10
#2Xinjing WangH-Index: 7
Last. Baiyong ShenH-Index: 19
view all 8 authors...
Early detection of postoperative pancreatic fistula (POPF) may help to improve the outcome following pancreatic surgery, and exclusion of POPF may allow early drain removal which can accelerate recovery. The aim of this study was to evaluate the diagnostic accuracy of drain/plasma pancreatic amylase values on postoperative day 1 (DPA1/PPA1) in POPF by means of a systemic review and meta-analysis. Online journal databases and a manual search up to March 2015 were used. Studies clearly documenting...
3 CitationsSource
#1Jing Xie (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiongxiong Lu (SJTU: Shanghai Jiao Tong University)H-Index: 10
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 19 authors...
Background Targeted therapies including monoclonal antibodies and small molecule inhibitors have dramatically changed the treatment of cancer over past 10 years. Their therapeutic advantages are more tumor specific and with less side effects. For precisely tailoring available targeted therapies to each individual or a subset of cancer patients, next-generation sequencing (NGS) has been utilized as a promising diagnosis tool with its advantages of accuracy, sensitivity, and high throughput. Metho...
4 CitationsSource
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